Fluorinated alcohol mediated N,N ′-dialkylation of amino acid derivatives via cascade [1,5]-hydride transfer/cyclization for concise synthesis of tetrahydroquinazoline

Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/C9OB02498K, PaperHongjin Shi, Lubin Xu, Didi Ren, Liang Wang, Weisi Guo, Shuai-Shuai Li Structurally diverse amino acids and their ester derivatives were convenientlyN,N′-dialkylatedvia TFE promoted cascade condensation/[1,5]-hydride transfer/cyclization for straightforward construction of tetrahydroquinazolines incorporating various amino acids. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry

Source: RSC - Organic and Biomolecular Chemistry - January 9, 2020 Category: Molecular Biology Authors: Hongjin Shi Source Type: research