Obstructive sleep apnoea severity and liver steatosis measured by magnetic resonance imaging

Obstructive sleep apnoea (OSA) and non-alcoholic fatty liver disease (NAFLD) are two of many diseases associated with obesity. NAFLD is a common condition ranging in severity from liver steatosis to non-alcoholic steatohepatitis and liver fibrosis, the last step of NAFLD progression. Numerous studies have investigated whether the frequent co-occurrence of OSA and NAFLD simply reflects their link to obesity, or whether there is an independent pathophysiological interconnection between the two diseases (see [1] for comprehensive review). In animal models, intermittent hypoxia mimicking OSA has been shown to cause insulin resistance, dysfunction of key steps in hepatic lipid metabolism, liver steatosis and fibrosis [1].

Source: European Respiratory Journal - January 8, 2020 Category: Respiratory Medicine Authors: Trzepizur, W., Boursier, J., Berrehare, A., Le Vaillant, M., Andriantsitohaina, R., Ducluzeau, P.-H., Dubois, S., Henni, S., Abraham, P., Cales, P., Aube, C., Paisant, A., Gagnadoux, F., on the behalf of the METABOL group Tags: Original Articles: Research letters Source Type: research