Effect of splenic flexure mobilization performed via medial-to-lateral and superior-to-inferior approach on early clinical outcomes in elective laparoscopic resection of rectal cancer.

Conclusions: Splenic flexure mobilization performed via the superior-to-inferior and medial-to-lateral approach appears to be a safe and feasible procedure. PMID: 31908696 [PubMed]
Source: Videosurgery and Other Miniinvasive Techniques - Category: Surgery Tags: Wideochir Inne Tech Maloinwazyjne Source Type: research

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We present here a case of prostate cancer with an uncommon inguinal canal deposit that was detected on 68Ga–prostate-specific membrane antigen PET/CT.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Objective: Gastrointestinal cancers are increasingly being treated with NAT before surgical resection. Currently, quality metrics are linked to the number of LNs resected to determine subsequent treatment and prognosis. We hypothesize that NAT decreases LN metastasis, downstages patients, and decreases overall lymph node yields (LNY) compared to initial surgical resection. With increasing use of NAT, this brings into question the validity of quality metrics. Methods: Gastric (stage II/III), pancreatic (stage I/II/III), and rectal cancers (stage II/III) (2010–2015) treated with surgery with/without NAT were ident...
warth D Abstract MR-guided radiotherapy requires novel QA methods for IMRT treatment plans (TPs). Here, an optimized method for TPs for a 1.5 T MR-linac was developed and implemented clinically. A static solid phantom and an MR-compatible 2D ionization chamber array were used. The array's response with respect to the incident beam gantry angles was characterized for four different orientations of the array relative to the beam. A lookup table was created identifying the optimum orientation for each gantry angle. For the QA of clinical MR-linac TPs, beams were grouped according to their gantry angles and measured w...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research
ConclusionModerate evidence suggests that delayed resection of colorectal cancer worsens survival; the impact of time to surgery on gastric and pancreatic cancer outcomes is uncertain. Early resection of gastrointestinal malignancies provides the best chance for curative therapy. During the COVID-19 pandemic, prioritization of procedures should account for available evidence on time to surgery and oncologic outcomes.
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
Abstract Objectives: We aimed to evaluate the possible role of dietray TAC against different types of cancers in a systematic review and meta-analyses of observational studies. Methods: A literature search of authentic electronic resources had been performed to obtain the relevant studies up to February 2020. Results: Twenty-one studies including nine prospective and twelve case-control studies were included in the current systematic review and meta-analysis. These studies have included 1404297 individuals. Higher TAC categories were associated with 21% reduced risk of colorectal cancer, 27% reduced risk of endome...
Source: Nutrition and Cancer - Category: Cancer & Oncology Authors: Tags: Nutr Cancer Source Type: research
CONCLUSION: Although the effectiveness of IORT cannot be finally assessed due to limited evidence, IORT is established in the clinical practice as a supplement to the multimodal treatment of (recurrent) rectal cancer and sarcomas. Gastric and pancreatic carcinomas are further indications but additional studies are necessary to clearly define the role of IORT in these tumor entities. An important factor to achieve a benefit with IORT seems to be patient selection in order to obtain good local control of local recurrences as well as overall survival rates for patients with primary or recurrent cancer. PMID: 3235055...
Source: Der Chirurg - Category: Surgery Authors: Tags: Chirurg Source Type: research
(Mary Ann Liebert, Inc./Genetic Engineering News) A new study has shown a novel peptide antagonist, given in combination with a PD-1 inhibitor, to be safe and well-tolerated in patients with advanced, refractory pancreatic and rectal cancer.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
In this study, two pathologists with expertise in pancreatic cancer used 4 of the most frequently reported systems (College of American Pathologists, Evans, MD Anderson, and Hartman) to evaluate tumor regression in 29 locally advanced pancreatic cancers previously treated with modified FOLFIRINOX regimen, to establish the level of agreement between pathologists and to determine their potential prognostic value. Cases were additionally evaluated with a fifth grading system inspired to the Dworak score, normally used for colo-rectal cancer, to identify an alternative, relevant option. Results obtained for current grading sys...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
This article is part of a Special Issue entitled: GSK-3 and related kinases in cancer, neurological and other disorders edited by James McCubrey, Agnieszka Gizak and Dariusz Rakus.
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - Category: Molecular Biology Source Type: research
In this study, we reviewed major human studies on the health risks of radiation exposure and showed that sex-related factors may potentially influence the long-term response to radiation exposure. Available data suggest that long-term radiosensitivity in women is higher than that in men who receive a comparable dose of radiation. The report on the biological effects of ionizing radiation (BEIR VII) published in 2006 by the National Academy of Sciences, United States emphasized that women may be at significantly greater risk of suffering and dying from radiation-induced cancer than men exposed to the same dose of radiation....
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
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