Hypoxia: a barricade to conquer the pancreatic cancer.

Hypoxia: a barricade to conquer the pancreatic cancer.
Cell Mol Life Sci. 2020 Jan 06;:
Authors: Tan Z, Xu J, Zhang B, Shi S, Yu X, Liang C
Abstract
Pancreatic cancer (PC) remains one of the most extremely lethal malignancies worldwide due to late diagnosis and early metastasis, with a 1-year overall survival rate of approximately 20%. The hypoxic microenvironment, induced by intratumoral hypoxia, promotes tumor invasion and progression, leading to chemotherapy or radiotherapy resistance and eventual mortality after treatment of PC. However, the role of the hypoxic microenvironment in PC is complicated and requires further investigation. In this article, we review recent advances regarding the regulation of malignant behaviors in PC, which provide insight into the potential of hypoxic microenvironment activation therapy for the therapeutic agents.
PMID: 31907561 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - January 5, 2020 Category: Cytology Authors: Tan Z, Xu J, Zhang B, Shi S, Yu X, Liang C Tags: Cell Mol Life Sci Source Type: research