Misoprostol administration prior to intrauterine contraceptive device insertion: a systematic review and meta-analysis of randomised controlled trials.

Conclusion: Our data demonstrate reduced IUCD insertion failure among women with previous caesarean section and those with previous IUCD insertion failure, suggesting that misoprostol may be a reasonable choice in these groups of women. Although misoprostol premedication reduced insertion failures, it significantly increased side effects and had a heterogeneous pattern of efficacy; thus, its routine use is not supported by the evidence. PMID: 31914331 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31914331?dopt=Abstract

Source: The European Journal of Contraception and Reproductive Health Care - January 7, 2020 Category: Reproduction Medicine Authors: Tassi A, Parisi N, Londero AP Tags: Eur J Contracept Reprod Health Care Source Type: research