Radiation Biomarkers: Can Small Businesses Drive Accurate Radiation Precision Medicine?

Radiation Biomarkers: Can Small Businesses Drive Accurate Radiation Precision Medicine? Radiat Res. 2020 Jan 07;: Authors: Prasanna PGS, Narayanan D, Zhang K, Rahbar A, Coleman CN, Vikram B Abstract Radiation therapy is an essential component of cancer treatment. Currently, tumor control and normal tissue complication probabilities derived from a general patient population guide radiation treatment. Its outcome could be improved if radiation biomarkers could be incorporated into approaches to treatment. A substantial number of cancer patients suffer from side effects of radiation therapy. These side effects can result in treatment interruption. Such unplanned treatment interruptions not only jeopardize anti-cancer treatment efficacy but also result in poor post-treatment quality-of-life. To develop and translate radiation biomarkers for clinical use, NCI's Radiation Research Program, in collaboration with the Small Business Innovation Research Development Center, funded four small businesses through the request for proposals after peer review during 2015-2019. Here, we summarize publicly available information on intellectual property rights, the status of development, ongoing clinical trials, success in obtaining financing and regulatory approval. An analysis of publicly available information indicates all four companies have completed phase I of SBIR funding and advanced to further development, validation and clinical trials with ph...
Source: Radiation Research - Category: Physics Authors: Tags: Radiat Res Source Type: research