Iron sequestrant DIBI, potential alternative for nares decolonization of MRSA Staphylococcus aureus, is anti-infective and inhibitory for mupirocin resistant isolates.

Iron sequestrant DIBI, potential alternative for nares decolonization of MRSA Staphylococcus aureus, is anti-infective and inhibitory for mupirocin resistant isolates.
Antimicrob Agents Chemother. 2020 Jan 06;:
Authors: Allan DS, Del Carmen Parquet M, Savage KA, Holbein BE
Abstract
MRSA opportunistic infections are a major health burden. Decolonization of hospitalized patients with mupirocin (MUP) has reduced infection incidence but has led to MUP resistance. DIBI is a developmental-stage anti-infective that sequesters bacterial iron and bolsters innate host iron withdrawal defences. Clinical isolates possessing low, high or no MUP-resistance all had similarly high susceptibilities to DIBI. Intranasal DIBI reduced nares bacterial burdens in mice to the same extent as MUP. No resistance was found following exposure to DIBI.
PMID: 31907189 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - January 5, 2020 Category: Microbiology Authors: Allan DS, Del Carmen Parquet M, Savage KA, Holbein BE Tags: Antimicrob Agents Chemother Source Type: research