Why we should study osteoarthritis pain in experimental models in both sexes

Females and males show clear differences in their susceptibility to many diseases, notably autoimmune diseases and malignancies, but also certain infectious diseases [1]. In addition to sex differences in disease susceptibility, there is abundant epidemiological and experimental evidence that sex is a major determinant of pain. Women are markedly overrepresented in chronic pain states, including several painful musculoskeletal conditions such as low back pain, fibromyalgia, and myofascial pain [2-4].
Source: Osteoarthritis and Cartilage - Category: Rheumatology Authors: Tags: Editorial Source Type: research