Pilot Centers for Precision Disease Modeling (U54)(Clinical Trials Not Allowed)

Funding Opportunity PAR-20-085 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites U54 cooperative agreement applications for Pilot Centers for Precision Disease Modeling. The goal of the Centers is to support collaborative research projects that link current personalized medicine efforts in human subjects with advances in animal genomics and technologies for genetic manipulation and creation of interspecies somatic hybrids. Functionally linking these areas of research will produce programs to enhance the predictive value of preclinical studies based on the use of precision animal models. Centers will create a process by which the research community can nominate unique human genomic variants for a cost effective high-throughput testing in an animal model pipeline. After validation of the expected gene editing, the Centers will establish assays to conduct comprehensive functional and phenotyping analysis to evaluate disease-causing variants. An important mission of the Centers will be the creation and distribution of precision animal model resources and related services to the biomedical community. Therefore, Centers will establish pipelines for preclinical scientific discovery, disease modeling, and development of interventions based on innovative animal models. Because these preclinical pipelines eventually will be an integral part of diagnostics, care and therapeutic treatment of patients, Centers should demonstrate how they i...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding