PTC1 and PTC2: New Indices of Blood Pressure Waveforms and Cardiovascular Disease.

PTC1 and PTC2: New Indices of Blood Pressure Waveforms and Cardiovascular Disease. Am J Epidemiol. 2020 Jan 07;: Authors: Brumback LC, Jacobs DR, Duprez DA Abstract Systolic and diastolic blood pressures provide information about cardiovascular disease (CVD) but are only extremes of the pressure waveform during the cardiac cycle. We developed summaries of the pressure decay, PTC1 and PTC2, that are related to arterial compliance and to an existing proprietary summary which has been shown to predict CVD. We derived the summaries from a Windkessel model (consisting of a decaying exponential plus a dampened cosine, and an intercept so they are independent of calibration with blood pressure, unlike the proprietary measures), and estimated them using nonlinear least squares with standard, free software. Among 6228 adults from the Multi-Ethnic Study of Atherosclerosis, initially free of CVD in 2000-2002, mean ± standard deviation of PTC2 was 94±46 milliseconds. During median 15 year follow-up, there were 911 CVD events (including 609 coronary heart disease and 270 strokes). One standard deviation higher PTC2 was associated with 17% (95% confidence interval: 10,24) lower CVD risk, after adjustment for traditional risk factors. Results were similar for PTC1. PTC1 and PTC2 are relatively straightforward to compute and add information beyond traditional risk factors for prediction of CVD. Our work enables others to replicate and extend our r...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research