Childbearing is Associated with a Short-term Reduced Risk of Crohn's Disease in Mothers.

Childbearing is Associated with a Short-term Reduced Risk of Crohn's Disease in Mothers. Am J Epidemiol. 2020 Jan 07;: Authors: Kravdal Ø, Magnus P, Moum B, Høivik ML Abstract The aim was to analyse the importance of childbearing for inflammatory bowel disease risks. Using data from the Norwegian Population Register and the Norwegian Patient Register, discrete-time hazard models for diagnosis of Crohn's disease (CD) or ulcerative colitis (UC) were estimated for men and women of age 18-81 in 2011-2016. Year and various socio-demographic factors were controlled for. The data included 4304 CD and 8866 UC cases. Women whose youngest child was 0-4 years old had lower CD risk the following year than the childless (OR 0.73, CI: 0.62, 0.86). There was no such reduction in CD risk among fathers. Men whose youngest child was older than 20 had higher CD risk (OR 1.22, CI: 1.01, 1.49) and UC risk (OR 1.15, CI: 1.02, 1.30) than the childless. The UC risk was also increased among men whose youngest child was aged 0-4 (OR 1.14, CI: 1.02, 1.27). The short-term reduction of women's CD risk after a birth may reflect biological effects of the pregnancy. Alternatively, it may reflect residual confounding or lifestyle effects of parenthood that are of special relevance for CD in women. In particular, differences in use of oral contraception (not possible to control for) may contribute to the observed pattern. PMID: 31907543 [PubMed - as supplie...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research