SOHO State of the Art Updates and Next Questions: High incidence of clonal CD8+ T-cell proliferation in non-malignant conditions may reduce the significance of T-cell clonality assay for differential diagnosis in oncohematology

The presence of clonal CD8+CD57+ cells in blood is common for healthy individuals and patients with reactive conditions and may not associate with any malignancy. T-cell monoclonality cannot perceive as an exclusive argument in favor of T-LGL leukemia diagnosis. Different levels of specificity for certain TCRG/ D β-Jβ TRB/ Vβ-Jβ TCRB PCR reactions should be taken into account for accurate T-cell clonality data interpretation.

Source: Clinical Lymphoma, Myeloma and Leukemia - January 7, 2020 Category: Hematology Authors: Yulia V. Sidorova, Kseniya A. Sychevskaya, Nataliya G. Chernova, Hunan L. Julhakyan, Svetlana Ju. Smirnova, Nataliya V. Ryzhikova, Vadim R. Gorodetskiy, Elena V. Naumova, Andrey B. Sudarikov Tags: Current Trial Report Source Type: research