Creation of a Registry to Address Knowledge Gaps in Hidradenitis Suppurativa and Pregnancy —Reply
In Reply We thank Adelekun and colleagues for their response to our Editorial calling for accelerated hidradenitis suppurativa (HS) research and improved care of patients with HS. We wholeheartedly agree that more evidence about the effects of HS on fertility, pregnancy, maternal and fetal outcomes, and lactation is needed to help guide optimal care of patients with HS who are of childbearing potential.
guez Luis F PMID: 31937445 [PubMed - as supplied by publisher]
To the Editor We read with interest the Editorial by Naik and Lowes and agree that there is an urgent need to advance knowledge in hidradenitis suppurativa (HS). We wish to highlight a particularly vulnerable but overlooked population with HS: those who are pregnant or seeking to become pregnant.
ConclusionThe existing studies do not allow a robust evidence-based recommendation for the use of antiandrogens in the treatment of hidradenitis suppurativa/acne inversa. Further randomized controlled trials are needed to define the role of hormonal treatment as an alternative or concomitant therapy together with antibiotics or biologics.
ConclusionThis report describes the successful surgical management of a pregnant woman with severe HS of the breast. This represents an alternative management method in an extreme case of HS, where aggressive medical management was contraindicated.
This article is protected by copyright. All rights reserved. PMID: 28718895 [PubMed - as supplied by publisher]
This article is protected by copyright. All rights reserved.
Hidradenitis suppurativa (HS) is an inflammatory skin disease. Several observations imply that sex hormones may play a role in its pathogenesis. HS is more common in women, and the disease severity appears to vary in intensity according to the menstrual cycle. In addition, parallels have been drawn between HS and acne vulgaris, suggesting that sex hormones may play a role in the condition. The role of androgens and estrogens in HS has therefore been explored in numerous observational and some interventional studies; however, the studies have often reported conflicting results. This systematic review includes 59 unique arti...
Hidradenitis suppurativa is a debilitating inflammatory skin disease with a chronic course and often disappointing response to treatment. Though a minority of persons (20%) reports symptom remission during pregnancy, the vast majority experiences no relief (72%), and few experience clinical deterioration (8%). Disease flares are also observed post-partum. The pathophysiological basis for pregnancy-associated fluctuations in clinical status is currently unknown. Because most women with HS require ongoing management throughout pregnancy, it is important to evaluate the suitability and safety of current treatment options for pregnant women.
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Abstract Hidradenitis suppurativa / acne inversa (HS) is a chronic inflammatory, debilitating skin disorder with a largely unknown etiology. However, many observations such as the typical onset of the disease after puberty, the female predominance, the pre-menstrual flare ups and the improvement during pregnancy suggest a contribution of endocrinological factors to the emergence of the disease. In addition, the reported efficacy of anti-androgen treatment on HS indicates a possible involvement of androgens in the pathogenesis. Furthermore, the common comorbidity with metabolic syndrome points to possible interacti...