Comparison of Therapeutic Benefit of Bupivacaine HCl Transversus Abdominis Plane (TAP) Block as Part of an Enhanced Recovery Pathway versus Traditional Oral and Intravenous Pain Control after Minimally Invasive Colorectal Surgery: A Prospective, Randomized, Double-Blind Trial.

This study evaluates the effectiveness of laparoscopic TAP blocks in conjunction with the benefit of an ERP. One hundred thirty-seven consecutive laparoscopic and robotic-assisted Colorectal Surgery patients received TAP blocks under laparoscopic guidance while under anesthesia, randomized to a placebo, bupivacaine TAP block, or bupivacaine TAP block with an ERP arm of the trial. Patient demographics, operative techniques, and postoperative outcomes were analyzed using statistical analysis software. Our main objective was to determine short-term benefits of TAP blocks on reducing total narcotic consumption. Secondary objectives included effects of TAP blocks on time to ambulation, time to bowel function, and LOS. To isolate the effect of the TAP blocks, no efforts were made to control nursing or patient education in patients managed without an ERP. Of 137 patients, 14 were withdrawn. All cases were elective, with the main diagnosis colon cancer or dysplastic polyps (47.1%). The median age in each group was comparable (P = 0.12), with female majority in both groups (58.5%). Most procedures were segmental colon resections (74.7%). Thirty-one patients received a placebo, 41 bupivacaine TAP, and 51 bupivacaine TAP plus ERP. In terms of primary endpoints, the bupivacaine plus ERP arm used statistically significant less IV narcotics on postoperative day 1 and in total (P = 0.001, P = 0.008). All patients ambulated on average within the first 24 hours postoperatively, with the TAP p...
Source: The American Surgeon - Category: Surgery Authors: Tags: Am Surg Source Type: research

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Publication date: 1 June 2020Source: Carbohydrate Polymers, Volume 237Author(s): Chayanaphat Chokradjaroen, Ratana Rujiravanit, Sewan Theeramunkong, Nagahiro Saito
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 30 March 2020Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): Lorenza González-Mariscal, Jael Miranda, Helios Gallego-Gutiérrez, Misael Cano-Cortina, Elida Amaya
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
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Source: Proteomics - Category: Biochemistry Authors: Tags: Review Source Type: research
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9NJ05449A, PaperYang Lei, Haixia Ye, Siqing Xiang, Yuan Huang, Chao Zhu, Weiying Zhang, Yong Chen, Qing Liang You Achieving dynamic regulation of cell-surface interactions is especially attractive for tissue engineering and cell-based treatment. Herein, we report a bottom-up approach for the generation of near-infrared (NIR)-controlled supramolecular “Pipette Device”... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
ABSTRACTGermicidal lamps that emit primarily 254 nm ultraviolet radiation (UV) are routinely utilized for surface sterilization but cannot be used for human skin because they cause genotoxicity. As an alternative, 222 nm ‐UVC have been reported to exert sterilizing ability comparable to that of 254 nm‐UVC without producing cyclobutane pyrimidine dimers (CPDs), the major DNA lesions caused by UV. However, there has been no clear evidence for safety in chronic exposure to skin, particularly with respect to carcino genesis. We therefore investigated the long‐term effects of 222 nm‐UVC on skin using a highly photocarci...
Source: Photochemistry and Photobiology - Category: Science Authors: Tags: RESEARCH ARTICLE Source Type: research
In this study the EGFR over‐expressing human head/neck OSC‐19‐luc2‐cGFP tumour with transfected GFP gen e was used in a skin‐fold window‐chamber model in BALB/c nude mice. The uptake and localization of the conjugate in the tumour and its surrounding normal tissues were studied by an intravital confocal laser scanning microscopy with image analyses. The tumour was also irradiated with 690 nm las er light 24 hours after conjugate administration. The vascular and tumour responses were examined by morphological evaluation and immunohistochemistry (IHC). The amount of conjugate in the tumour peaked at 24‐4...
Source: Photochemistry and Photobiology - Category: Science Authors: Tags: SPECIAL ISSUE RESEARCH ARTICLE Source Type: research
Contributors : Ivan Martinez ; Tayvia BrownmillerSeries Type : Expression profiling by arrayOrganism : Homo sapiensNumerous studies have implicated changes in the Y chromosome in male cancers, however few have investigated the biological importance of Y chromosome non-coding RNAs. Here, we demonstrate a group of Y chromosome-expressed long non-coding RNAs (lncRNAs) involved in male non-small cell lung cancer (NSCLC) radiation sensitivity. Radiosensitive male NSCLC cell lines demonstrated a dose-dependent induction of linc-SPRY3-2/3/4 following irradiation, not observed in radioresistant male NSCLC cell lines. Cytogenetics ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Authors: Angarita-Sierra T, Montañez-Méndez A, Toro-Sánchez T, Rodríguez-Vargas A Abstract Envenomations by colubrid snakes in Colombia are poorly known, consequently, the clinical relevance of these species in snakebite accidents has been historically underestimated. Herein, we report the first case of envenomation by opisthoglyphous snakes in Colombia occurred under fieldwork conditions at the municipality of Distracción, in the department of La Guajira. A female biologist was bitten on the index finger knuckle of her right hand when she tried to handle a false fer-de-lance snak...
Source: Biomedica : Revista del Instituto Nacional de Salud - Category: International Medicine & Public Health Tags: Biomedica Source Type: research
CONCLUSIONS: TAMIS is an innovative technique that may be considered for the treatment of benign diseases like anastomotic complications, benign rectal stenosis, anastomotic explorations with lavage and drainage, rectal ulcus, and rectal intussusception. It can be used to search for a good plane of dissection, which cannot be found through the abdominal anterior approach. It can also be adopted for removal of early malignant rectal polyps and for TaTME. The technique described here allows the surgeons to work under ergonomic conditions, with completely reusable materials, and with a magnified view of the operative field, a...
Source: Surgical Technology International - Category: Surgery Tags: Surg Technol Int Source Type: research
ABSTRACT Vesicoureteral reflux, the retrograde flow of urine from the bladder into the upper urinary tract, is one of the most common urologic diagnoses in the pediatric population. Once detected, therapeutic options for urinary reflux are diverse, ranging from observation with or without continuous low-dose prophylactic antibiotics to a variety of operative interventions. While a standardized algorithm is lacking, it is generally accepted that management be tailored to individual patients based on various factors including age, likelihood of spontaneous resolution, risk of subsequent urinary tract infections with renal pa...
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
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