Inflammation factors and element supplementation in cancer

Publication date: Available online 8 January 2020Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Małgorzata Jelińska, Dorota Skrajnowska, Małgorzata Wrzosek, Kamila Domanska, Wojciech Bielecki, Marta Zawistowska, Barbara Bobrowska KorczakAbstractThe aim of the study was to evaluate the effect of dietary supplementation with chosen minerals (Zn, Se, Fe) on expression of selected cytokines (IL-1, IL-6, TNFα) in spleen of rats and on their concentrations in rat serum under inflammatory and pathological conditions obtained by implantation of prostate cancer cells (LnCaP). Serum levels of metabolites of arachidonic, eicosapentaenoic and linoleic acids (hydroxyeicosatetraenoic, hydroxyeicosapentaenoic and hydroxyoctadecadienoic acids, respectively), as compounds involved in inflammation and cancer development, were also investigated. Male rats were randomised into dietary groups supplemented with Zn, Se or Fe. Prostate cancer cells were implanted to some rats in each group.The study demonstrated that minerals supplemented with the diet may exert various effects on an organism. Selenium, zinc and iron influence pro-inflammatory cytokine expression, what leads to stimulation of inflammation. They also affect synthesis of arachidonic and linoleic acid metabolites that exert pro-inflammatory action and enable cancer development and metastasis.
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research