Aspirin moderates the association between cardiovascular risk, brain white matter hyperintensity total lesion volume and processing speed in normal ageing

Low-dose aspirin reduces the frequency of adverse vascular events in those at increased risk of occlusive cardiovascular disease (CVD). People who benefit include those: with a history of myocardial infarction, ischaemic stroke, unstable or stable angina, peripheral arterial disease, or atrial fibrillation (1). The pathophysiology of CVD risk contributes to cognitive decline through multiple pathways that include cerebral hypo-perfusion, hypoxia, hippocampal atrophy, emboli, or infarcts (2,3). However, the value of aspirin use in prevention of cognitive impairment remains uncertain since results relating to the influence of taking aspirin on cognitive function are inconsistent (4 –6).

Source: Maturitas - January 6, 2020 Category: Primary Care Authors: Mina Khezrian, Jennifer M.J. Waymont, Phyo K. Myint, Christopher J. McNeil, Lawrence J. Whalley, Roger Staff, Alison D. Murray Source Type: research