Renal Outcomes in Patients Bridged to Heart Transplant with a Left Ventricular Assist Device.

Renal Outcomes in Patients Bridged to Heart Transplant with a Left Ventricular Assist Device. Ann Thorac Surg. 2020 Jan 02;: Authors: Jawitz OK, Fudim M, Raman V, Blumer VL, Caliskan K, DeVore AD, Mentz RJ, Milano C, Soliman O, Rogers J, Patel C Abstract BACKGROUND: Patients with end stage heart failure are increasingly being bridged to heart transplant (BTT) with mechanical circulatory support (MCS), however the association between a left ventricular assist device (LVAD) BTT strategy and post-transplant renal outcomes is unclear. The aim of this study was to analyze the association of LVAD BTT with the development of post-transplant renal failure using a large national registry. METHODS: We queried the 2009-2018 United Network for Organ Sharing (UNOS) registry for all adults undergoing first-time heart or heart-kidney transplantation and stratified patients by use of pre-transplant durable LVAD. The primary outcome of interest was post-transplant renal failure, which was evaluated with multivariable logistic regression. RESULTS: 18,307 patients met inclusion criteria including 7,887 (43%) and 10,420 (57%) that were and were not bridged to transplant with an LVAD, respectively. BTT patients had slightly better baseline renal function (eGFR 68.7 vs 65.8 mL/min, p
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research

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Conditions:   Heart Transplant Infection;   CMV Infection Intervention:   Diagnostic Test: ELISPOT IFN-γ assay Sponsors:   Hospital Universitari de Bellvitge;   Instituto de Salud Carlos III;   Sociedad Española de Cardiología Not yet recruiting
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Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
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