Metformin-repressed miR-381-YAP-snail axis activity disrupts NSCLC growth and metastasis.

CONCLUSIONS: Metformin-induced repression of miR-381-YAP-Snail axis activity disrupts NSCLC growth and metastasis. Thus, we believe that the miR-381-YAP-Snail signal axis may be a suitable diagnostic marker and a potential therapeutic target for lung cancer.
PMID: 31906986 [PubMed - in process]

Source: Clinical Genitourinary Cancer - January 5, 2020 Category: Cancer & Oncology Authors: Jin D, Guo J, Wu Y, Chen W, Du J, Yang L, Wang X, Gong K, Dai J, Miao S, Li X, Su G Tags: J Exp Clin Cancer Res Source Type: research