Enhanced CaMKII-Dependent Late INa Induces Atrial Pro-Arrhythmic Activity in Patients with Sleep-Disordered Breathing.

Conclusions: In atrial myocardium of SDB patients, increased CaMKII-dependent phosphorylation of NaV1.5 results in dysregulation of INa with pro-arrhythmic activity that was independent from pre-existing co-morbidities. Inhibition of CaMKII may be useful for prevention or treatment of arrhythmias in SDB.
PMID: 31902278 [PubMed - as supplied by publisher]

Source: Circulation Research - January 5, 2020 Category: Cardiology Authors: Lebek S, Pichler K, Reuthner K, Trum M, Tafelmeier M, Mustroph J, Camboni D, Rupprecht L, Schmid C, Maier LS, Arzt M, Wagner S Tags: Circ Res Source Type: research