Biomarker-Specific Differences Between Transpulmonary and Peripheral Arterial-Venous Blood Sampling in Patients with Pulmonary Hypertension.

Biomarker-Specific Differences Between Transpulmonary and Peripheral Arterial-Venous Blood Sampling in Patients with Pulmonary Hypertension. Biomarkers. 2020 Jan 04;:1-20 Authors: Meoli DF, Clark DE, Davogustto G, Su YR, Brittain EL, Hemnes AR, Monahan K Abstract PURPOSE: Transpulmonary biomarkers may provide insight into pulmonary hypertension (PH) pathophysiology, but require cardiac catheterization. We investigated whether the peripheral arterial/venous ratio (PR) could substitute for the transpulmonary ratio (TPR). MATERIALS AND METHODS: Blood from the pulmonary artery (PA), pulmonary arterial wedge (PAW), peripheral venous, and peripheral arterial positions was analyzed for ET-1, NT-pro-BNP, and cAMP levels in subjects with no PH (n = 18) and PH due to left heart disease (PH-LHD), which included combined pre- and post- capillary PH (Cpc-PH; n = 7) and isolated post-capillary PH (Ipc-PH; n = 9). Bland-Altman comparisons were made between peripheral venous and PA samples and between peripheral arterial and PAW samples. TPR was defined as [PAW]/[PA]. RESULTS: For ET-1, Bland-Altman analysis indicated negative bias (-24%) in peripheral arterial compared to PAW concentration and positive bias (23%) in peripheral venous compared to PA concentration. There was
Source: Biomarkers - Category: Research Tags: Biomarkers Source Type: research

Related Links:

AbstractPulmonary arterial hypertension (PAH) related to left-to-right shunt can progress to Eisenmenger syndrome, a serious and fatal disease that is not yet curable. This pilot study considered stem cell injection as a new treatment modality in persistent pulmonary hypertension after the correction of a congenital heart defect. Three patients with persistent pulmonary hypertension after ventricular septal defect repair were included in this pilot study for a clinical trial. Mononuclear stem cells derived from patients ’ bone marrow specimens were injected into the right and left pulmonary arteries via cardiac cathe...
Source: Mammalian Genome - Category: Genetics & Stem Cells Source Type: research
Conclusions: We developed a new preclinical model of Group 2 PH and showed that MetS exacerbates SAB-induced PH-LHD. We displayed that IL-6 promotes SAB-induced pulmonary vascular remodeling and PH-LHD. We proposed IL-6 as a therapeutic target in Groups 2 PH
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Right ventricle Source Type: research
Abstract Pulmonary hypertension is a term used to describe a complex multifactorial group of conditions diagnosed by an elevated mean pulmonary artery pressure of 20 mm Hg or higher on right heart catheterization. The diagnosis of pulmonary hypertension in pregnancy is important, as it is associated with high rates of maternal morbidity and mortality, even with modern management. Diagnostic testing is important for establishing the diagnosis, type, and severity of pulmonary hypertension, which in turn, dictates treatment options. Echocardiographic assessment is the first step in diagnosis and the gold standard for...
Source: Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Obstet Gynecol Source Type: research
CONCLUSION: The results of this study indicated that the impact of the new definition of PH on the number of pre-capillary PH patients identified was greater than the predicted
Source: Turk Kardiyoloji Dernegi arsivi - Category: Cardiology Authors: Tags: Turk Kardiyol Dern Ars Source Type: research
We describe a female infant with incontinentia pigmenti complicated by severe pulmonary arterial hypertension that was markedly improved by tadalafil administration. The infant was referred to our institution because of neonatal seizures and generalized skin rash at the age of 1 day. She was diagnosed with incontinentia pigmenti on skin biopsy findings. In addition to incontinentia pigmenti, she had pulmonary arterial hypertension without structural heart disease. The pulmonary hypertension rapidly worsened at the age of 2 months and was confirmed by cardiac catheterization. The pulmonary artery pressure was equal to syste...
Source: European Journal of Medical Genetics - Category: Genetics & Stem Cells Authors: Tags: Eur J Med Genet Source Type: research
Publication date: Available online 29 July 2019Source: Archives of Cardiovascular Diseases SupplementsAuthor(s): Marine Tortigue, Nidhal Ben Moussa, Olivier Sitbon, David Montani, Xavier Jaïs, Laurent Savale, Florence Parent, Florence Lecerf, Emmanuelle Fournier, Sarah Cohen, Louis Moisson, Marc Humbert, Marc-Antoine Isorni, Sébastien HascoetIntroductionRight heart catheterization is an invasive exam that is currently the gold standard to assess pulmonary hemodynamics for diagnosis and follow-up of pulmonary arterial hypertension (PAH) associated with congenital heart diseases (CHD). Cardiac magnetic resonance ...
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
Right ventricular (RV) failure with pulmonary hypertension (PH) is frequently encountered in patients with advanced left-sided heart disease (LHD). However, RV energetics in patients with postcapillary PH because of LHD has not been well studied. The authors investigated intraoperative RV energetics in patients with PH due to LHD based on pressure –volume curves with three-dimensional transesophageal echocardiography and pulmonary artery catheterization.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Original Article Source Type: research
CONCLUSIONS: We developed a new preclinical model of Group2-PH by combining MetS with LHD. We showed that MetS exacerbates Group 2 PH. We provided evidence for the importance of the IL-6-STAT3 pathway in our experimental model of Group2-PH and human patients. PMID: 31154939 [PubMed - as supplied by publisher]
Source: Circulation Research - Category: Cardiology Authors: Tags: Circ Res Source Type: research
Pulmonary hypertension (PH) is a life-threatening condition and generally confers a poor prognosis. Among the various etiologies, left heart disease is the most common cause of the development of PH.1 The presence of PH in heart failure (HF) is associated with more severe symptom and worse exercise tolerance.2 PH also has negative impact on the clinical outcome both in HF with preserved ejection fraction (HFpEF)3 and reduced ejection fraction (HFrEF).4 Since the definite diagnosis of PH, defined as mean pulmonary artery pressure (mPAP) more than 25 mmHg, requires right heart catheterization, non-invasive methods such as tr...
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Source Type: research
CONCLUSION: Although the criteria for positive AVT currently used are unsuitable for pediatric PAH-CHD patients, PVR and PVR/SVR during AVT are excellent predictors of outcome in pediatric PAH-CHD. Surgery aided by anti-PAH drugs is an effective strategy and should be recommended for severe pediatric PAH-CHD with PVR ≤ 6.65 WU/m and PVR/SVR ≤ 0.39 after iloprost aerosol inhalation.This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. T...
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
More News: Cardiac Catheterization | Cardiology | Heart | Heart Disease | Hypertension | Pulmonary Artery Catheterization | Pulmonary Hypertension | Research