Ectopic Corticotropin-Releasing Hormone–Secreting Pancreatic Neuroendocrine Tumor: Excellent Response of Liver Metastases to Peptide Receptor Radionuclide Therapy as Demonstrated by: 68: Ga-DOTATOC and: 18: F-FDG PET/CT Imaging

We report here the case of a 54-year-old man who experienced CRH-secreting pancreatic neuroendocrine tumor causing Cushing syndrome, initially detected by SSTR (somatostatin receptor) scintigraphy, then significantly progressed with multiple liver metastases, demonstrating significantly increased SSTR expression on 68Ga-DOTATOC PET/CT and a “mismatch” imaging pattern on 18F-FDG PET/CT. The patient underwent peptide receptor radionuclide therapy with 177Lu/90Y-DOTATOC and demonstrated excellent response to the treatment.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research