Etiology, epidemiology, pathology, and advances in diagnosis, vaccine development, and treatment of Gallibacterium anatis infection in poultry: a review.

Etiology, epidemiology, pathology, and advances in diagnosis, vaccine development, and treatment of Gallibacterium anatis infection in poultry: a review. Vet Q. 2020 Jan 06;:1-32 Authors: Dharanesha NK, Dhama K, Mariappan AK, Munuswamy P, Mohd IY, Tiwari R, Karthik K, Bhatt P, Reddy MR Abstract Gallibacterium anatis is a Gram-negative bacterium of the Pasteurellaceae family that resides normally in the respiratory and reproductive tracts in poultry. It is a major cause of oophoritis, salpingitis, and peritonitis, decreases egg production and mortality in hens thereby severely affecting animal welfare and overall productivity by poultry industries across Europe, Asia, America, and Africa. In addition, it has the ability to infect wider host range including domesticated and free-ranging avian hosts as well as mammalian hosts such as cattle, pigs and human. Evaluating the common virulence factors including outer membrane vesicles, fimbriae, capsule, metalloproteases, biofilm formation, hemagglutinin, and determining novel factors such as the RTX-like toxin GtxA, elongation factor-Tu, and clustered regularly interspaced short palindromic repeats (CRISPR) has pathobiological, diagnostic, prophylactic, and therapeutic significance. Treating this bacterial pathogen with traditional antimicrobial drugs is discouraged owing to the emergence of widespread multidrug resistance, whereas the efficacy of preventing this disease by classical vaccines is limited due to i...
Source: Veterinary Quarterly - Category: Veterinary Research Tags: Vet Q Source Type: research

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CONCLUSION: These results suggested that rHP-NAP possesses the potential for use as an adjuvant of dendritic cell-based vaccine in anti-melanoma treatment. PMID: 32224538 [PubMed - in process]
Source: Iranian Journal of Immunology - Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research
CONCLUSION: Evaluation of immune status based on PD-L1 pleural concentration and Th2 to Th1 ratio might predict the risk of MDR-TB occurrence. PMID: 32224537 [PubMed - in process]
Source: Iranian Journal of Immunology - Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research
Please don't get me wrong. I've seen other people try to put our present crisis in context, or discuss the costs vs. the benefits of certain actions, and be widely condemned for insensitivity or even sociopathy. I remember after the 9/11 attack, when people who tried to explain the motivations or sociological origins of Al Qaeda and similar movements faced the same sort of criticism. You weren't allowed to think about the problem, people weren't ready for any sort of moral confusion. In what I am about to say, I am not arguing against saving lives, on the contrary. I'm just trying to explain something about where we are in...
Source: Stayin' Alive - Category: American Health Source Type: blogs
Purpose of review This review provides an overview of currently ongoing clinical trials evaluating the combination of immune checkpoint inhibitors (CPI) with other therapies in locally advanced or metastatic urothelial cancer and the rationale for this combination approach. We discuss the preliminary results from early data presented at recent meetings regarding the efficacy and safety of novel combination therapies including a CPI for metastatic urothelial cancer. Recent findings CPI emerged as novel first-line or second-line treatment options in advanced and metastatic urothelial cancer (mUC). Although the response ...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: BLADDER CANCER: Edited by Juan Palou and Óscar Rodríguez Faba Source Type: research
By Ehtesham ShahidDUBAI, Apr 1 2020 (IPS-Partners) Global crises need global solutions yet some adjustments will have to be made if the world has to adopt a multilateral approach toward tackling the Corona pandemic, a senior academic said on Tuesday, March 31. Participating in an e-symposium organized by the think-tank, TRENDS Research &Advisory, Prof. Yong Wang of the School of International Studies and Director, Center for International Political Economy at Peking University, said the G-20 has already taken an initiative and more such efforts are needed. “We have our national interests but for facing challenge...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Conferences Health Source Type: news
Cigarette maker says tobacco plants offer potential for faster and safer drug developmentCoronavirus – latest updatesSee all our coronavirus coverageBritish American Tobacco, the maker of brands including Lucky Strike, Dunhill, Rothmans and Benson&Hedges, has said it has a potential coronavirus vaccine in developmentusing tobacco plants.BAT has turned the vast resources usually focused on creating products that pose health risks to millions of smokers worldwide to battling the global pandemic.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: British American Tobacco Business Coronavirus outbreak Infectious diseases Medical research Microbiology Science World news UK news US news Source Type: news
CONCLUSIONS: The survey results suggest that dentists' comfort levels and perceived roles in discussing and administering the HPV vaccine vary. PRACTICAL IMPLICATIONS: There is a need to further define the role of dentists and their team members in the promotion and administration of the HPV vaccine. Resources for dentists and dental team members may be helpful to support professional education and communication about the HPV vaccine. PMID: 32222178 [PubMed - in process]
Source: Journal of the American Dental Association - Category: Dentistry Tags: J Am Dent Assoc Source Type: research
Scientists at the University of Bristol who have been sequencing the genetic material from SARS-CoV-2 — the virus that causes COVID-19 — have highlighted important implications for scientists around the world conducting vaccine trials aimed at preventing the disease. The findings are published on the preprint site bioRxiv.
Source: University of Bristol news - Category: Universities & Medical Training Tags: International, Research; Faculty of Life Sciences, Faculty of Life Sciences, School of Cellular and Molecular Medicine; Press Release Source Type: news
Tobacco maker’s unit uses technology in pre-clinical testing on animals
Source: - Drugs and Healthcare - Category: Pharmaceuticals Source Type: news
British American Tobacco, the maker of Dunhill and Lucky Strike cigarettes, said on Wednesday its U.S. biotech unit was working on a potential vaccine for COVID-19 using proteins extracted from tobacco leaves.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
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