Effects Of High Fat Diet And Intestinal Aryl Hydrocarbon Receptor Deletion On Colon Carcinogenesis.

Effects Of High Fat Diet And Intestinal Aryl Hydrocarbon Receptor Deletion On Colon Carcinogenesis. Am J Physiol Gastrointest Liver Physiol. 2020 Jan 06;: Authors: Garcia-Villatoro EL, DeLuca JA, Callaway ES, Allred KF, Davidson LA, Hensel ME, Menon R, Ivanov I, Safe S, Jayaraman A, Chapkin RS, Allred CD Abstract Consumption of a high-fat diet has been associated with an increased risk of developing colorectal cancer (CRC). However, the effects of the interaction between dietary fat content and the aryl hydrocarbon receptor (AhR) on colorectal carcinogenesis remain unclear. Mainly known for its role in xenobiotic metabolism, AhR has been identified as an important regulator for maintaining intestinal epithelial homeostasis. Although previous research using whole-body AhR knockout mice has revealed an increased incidence of colon and cecal tumors, the unique role of AhR activity in intestinal epithelial cells (IECs) and modifying effects of fat content in the diet at different stages of sporadic CRC development has yet to be elucidated. In the present study, we have examined the effects of a high-fat diet on IEC-specific AhR knockout mice in a model of sporadic CRC. While, loss of AhR activity in IECs significantly induced the development of premalignant lesions, in a separate experiment, no significant changes in colon mass incidence were observed. Moreover, consumption of a high-fat diet promoted cell proliferation in crypts at the ...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - Category: Physiology Authors: Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research