The risk of fractures, acute myocardial infarction, atrial fibrillation and ventricular arrhythmia in geriatric patients exposed to promethazine.

This study aimed to compare the risk of fractures, acute myocardial infarction, atrial fibrillation, and ventricular arrhythmia among Danish citizens aged ≥ 65 which were new users of promethazine or domperidone, triazolam, loratadine, and betahistine. Secondly, the study aimed to perform a risk stratification to identify the most relevant predictors for the study outcomes.Methods: The study period was 01/01/2015 to 31/12/2016. The data sources were the Danish registers. Each patient was followed for 90 days. A logistic regression model was used to compute the unadjusted and adjusted odds ratios (OR), and a conditional inference tree was used to identify the most relevant predictors for the study outcomes.Results: Promethazine had a higher risk of hospitalization for atrial fibrillation than loratadine and betahistine (OR 1.58; 95% CI 1.07-2.63 and OR 3.22; 95% CI 1.69-7.14, respectively). For fractures, acute myocardial infarction, and ventricular arrhythmia hospitalizations, no statistically significant differences were found among drugs under investigation. The medical history of cardiac arrhythmia (OR 4.14; 95% CI 2.94-5.78, p
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research

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Publication date: Available online 31 May 2020Source: SteroidsAuthor(s): Fernando A.C. Seara, Emerson L. Olivares, Jose H. M. Nascimento
Source: Steroids - Category: Drugs & Pharmacology Source Type: research
CONCLUSION: We report the successful management of anesthesia without lethal arrhythmia in a patient with ARVC and an ICD. An adequate amount of analgesia should be administered during general anesthesia to maintain adequate anesthetic depth and to avoid stress and pain. PMID: 32473832 [PubMed - as supplied by publisher]
Source: Revista Brasileira de Anestesiologia - Category: Anesthesiology Tags: Rev Bras Anestesiol Source Type: research
Conclusions Although ablation of CTI-dependent atrial flutter is a safe and effective procedure, 50% of the patients developed AF after the procedure. However, the role of combined ablation (CTI-dependent atrial flutter plus AF) aiming at preventing AF is still uncertain. (Arq Bras Cardiol. 2020; [online].ahead print, PP.0-0)
Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research
Conclusions Although ablation of CTI-dependent atrial flutter is a safe and effective procedure, 50% of the patients developed AF after the procedure. However, the role of combined ablation (CTI-dependent atrial flutter plus AF) aiming at preventing AF is still uncertain. (Arq Bras Cardiol. 2020; [online].ahead print, PP.0-0)
Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research
June 1, 2020 -- AstraZeneca’s Brilinta (ticagrelor) has been approved in the US to reduce the risk of a first heart attack or stroke in high-risk patients with coronary artery disease (CAD), the most common type of heart disease. The approval...
Source: Drugs.com - New Drug Approvals - Category: Drugs & Pharmacology Source Type: news
Publication date: Available online 1 June 2020Source: The Annals of Thoracic SurgeryAuthor(s): Giuseppe Nasso, Giuseppe Santarpino, Giuseppe Speziale
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Conditions:   Heart Failure;   Left Bundle-Branch Block Interventions:   Device: HIS/LBB pacing;   Device: LV pacing Sponsor:   Rigshospitalet, Denmark Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Posttraumatic Stress Disorder;   Prolonged Grief Disorder;   COVID Intervention:   Behavioral: Tele-delivered psychological intervention Sponsor:   Rigshospitalet, Denmark Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Hyperlactatemia;   Brain Tumor;   Surgery;   Anesthesia Interventions:   Other: Serum-lactate /=  2,2 mmol/L Sponsor:   Rigshospitalet, Denmark Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 30 May 2020Source: Indian Heart JournalAuthor(s): Aditya Kapoor, Rakesh Yadav
Source: Indian Heart Journal - Category: Cardiology Source Type: research
More News: Arrhythmia | Atrial Fibrillation | Cardiac Arrhythmia | Denmark Health | Drugs & Pharmacology | Geriatrics | Heart Attack | Promethazine | Statistics | Study | Ventricular Arrhythmia