Beneficial effect of GABA-rich fermented milk on insomnia involving regulation of gut microbiota

In this study, milk was fermented with Lactobacillus brevis DL1-11, a strain with high GABA-producing capacity. The potential beneficial effects of this fermented milk on anxiety and sleep quality were evaluated in animal experiments. Sixty mice were divided into control, non-GABA fermented milk (NGFM), low-dose GABA fermented milk (LGFM, 8.83 mg/, medium-dose GABA fermented milk (MGFM, 16.67 mg/, high-dose GABA fermented milk (HGFM, 33.33 mg/ and diazepam groups. The results of open field test and elevated plus-maze test indicated decreases in anxiety behavior after oral HGFM administration. Moreover, mice in the HGFM group exhibited a significantly prolonged sleep time after an intraperitoneal injection of sodium pentobarbital and a shortened sleep latency after an intraperitoneal injection of sodium barbital. These results indicate a beneficial effect of HGFM on sleep. Additionally, significant increases in the relative abundances of Ruminococcus, Adlercreutzia and Allobaculum and the levels of some short-chain fatty acids (SCFAs), such as butyric acid, were observed in the HGFM group. The results suggest that GABA-fermented milk may improve sleep and the protective pathways may involve in regulation of gut microbiota and increase of SCFAs level.Graphical abstract
Source: Microbiological Research - Category: Infectious Diseases Source Type: research

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Conclusion: This study will provide theoretical support for the clinical application of auricular point combined with moxibustion in the treatment of insomnia. Ethics and dissemination: The private information from individuals will not publish. This systematic review also will not involve endangering participant rights. Ethical approval is not required. The results may be published in a peer-reviewed journal or disseminated in relevant conferences. OSF Registration number: DOI 10.17605/OSF.IO/8VZRJ.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
DiscussionIt is expected that proACT-S is an efficacious brief sleep-focused self-help treatment for people with major depression and insomnia. If proven efficacious, due to its self-help nature, proACT-S may be applicable as a community-based early intervention, thereby  reducing the burden of the public healthcare system in Hong Kong.Trial registrationClinicalTrials.govNCT04228146. Retrospectively registered on 14 January 2020.
Source: Trials - Category: Research Source Type: clinical trials
Abstract Cognitive behavioural therapy for insomnia is the recommended treatment for chronic insomnia. However, up to a quarter of patients dropout from cognitive behavioural therapy for insomnia programmes. Acceptance, mindfulness and values-based actions may constitute complementary therapeutic tools to cognitive behavioural therapy for insomnia. The current study sought to evaluate the efficacy of a remotely delivered programme combining the main components of cognitive behavioural therapy for insomnia (sleep restriction and stimulus control) with the third-wave cognitive behavioural therapy acceptance and comm...
Source: Journal of Sleep Research - Category: Sleep Medicine Authors: Tags: J Sleep Res Source Type: research
CONCLUSION: These results identify clinical features of veterans and service members with mTBI(s) who are at highest risk for pain-related disability. These findings also demonstrate the need to consider mental health and sleep problems in their pain evaluation and treatment approach. PMID: 33007066 [PubMed - as supplied by publisher]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
CONCLUSIONS: Chronic insomnia is prevalent among OSA patients. Our study highlights the need for detailed evaluation of patients with sleep breathing disorders to diagnose other important sleep and mood disorders (such as depression and anxiety), given their frequent association. PMID: 32997071 [PubMed - as supplied by publisher]
Source: Revista Brasileira de Psiquiatria - Category: Psychiatry Authors: Tags: Braz J Psychiatry Source Type: research
Conditions:   Caffeine Dependence;   Anxiety;   Sleep Disturbance;   Gastrointestinal Dysfunction;   Sleep Initiation and Maintenance Disorders;   Caffeine; Sleep Disorder;   Caffeine;   Caffeine-Induced Anxiety Disorder;   Caffeine Withdrawal;   Caffeine-Induced Sleep Disorder, Without U se Disorder;   Caffeine Abuse;   Insomnia;   Anxiety Disorders;   Sleep Disorder;   Heartburn;   Diarrhea Intervention:   Behavioral: Caffeine Reduction Manual Spons...
Source: - Category: Research Source Type: clinical trials
This study showed an association between reduced REM and increased mortality, but it did not demonstrate the cause of the association. REM deprivation could independently contribute to the development of numerous other diseases. The results apply more clearly to older adults, given that the age groups studied averaged in the 50s and 70s. Short REM may also be a marker of a sick or aging brain; less REM sleep has already been tied to a greater risk of dementia. Overall, ensuring adequate REM sleep is important to protecting your long-term health. Getting better sleep in middle age and beyond Maintaining good sleep should re...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Brain and cognitive health Fatigue Memory Sleep Source Type: blogs
Rapid review question: What are the medium- and long-term health sequelae of COVID-19 infection among survivors? In brief: General health sequelae • Symptoms commonly reported among recovered COVID-19 patients two to eight weeks after the onset of symptoms (or a positive COVID-19 test) include: fatigue, shortness of breath, muscle or joint pain, chest pain, cough, and insomnia and/or sleep disorders.(1-6) • A study of 202 confirmed COVID -19 patients with mild symptoms, found altered sense of smell or taste occurred in 18.6% of patients, feelings of being tired in 13.1%, problems breathing in 10.4% and muscle or ...
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
This controlled clinical trial observed significant added benefit to reduce symptoms of insomnia with use of a closed ‐loop, acoustic stimulation neurotechnology that echoes tones linked to brainwaves (HIRREM), compared to a sham using randomly generated tones. There was also significant improvement in multiple measures of autonomic cardiovascular regulation, with durability to 4 months postintervention, and gro up differences for sleep efficiency, total sleep time, and sleep onset latency. Results suggest that this noninvasive, nondrug intervention could provide a viable alternative for moderate to severe insomnia....
Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research
We describe our efforts leading to the identification of a promising set of dual orexin receptor antagonists (DORAs) which subsequently went through physiology-based pharmacokinetic and pharmacodynamic modelling 1 and finally led to the selection of daridorexant ( 93 ) currently in phase 3 clinical trials for the treatment of insomnia disorders. PMID: 32937014 [PubMed - as supplied by publisher]
Source: ChemMedChem - Category: Chemistry Authors: Tags: ChemMedChem Source Type: research
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