25-Hydroxyvitamin D3 positively regulates periodontal inflammaging via SOCS3/STAT signaling in diabetic mice

ConclusionDiabetic periodontitis appeared to develop an inflammaging status resulted in periodontal infection. 25(OH)D3 could inhibit SASP secretion through reducing SOCS3 expression in experimental diabetic periodontitis, dependently inactivating NF-κB pro-inflammatory signaling. The reversible effect further documented that the inflammaging might be a highly likely contributor in diabetic periodontitis.Graphical abstract25(OH)D3 played the protective role in gingival tissue of db/db mice with periodontitis. SOCS3 is an endogenous negative regulator of the inflammaging. Diabetic periodontitis developed an inflammaging status with up-regulated SOCS3 in gingival tissue. Black arrows indicate pathogenic mechanism, wherein solid arrows indicate directly active effects and black dashed arrows indicate the indirectly active effects. Green solid arrows indicate the functions of 25(OH)D3, green bar-headed lines indicate inhibit effects.
Source: Steroids - Category: Drugs & Pharmacology Source Type: research