Six gene and TH2 signature expression in endobronchial biopsies of participants with asthma

Conclusions and Clinical RelevanceThere was increased expression ofDNASE1L3 in asthma andIL1B in neutrophilic asthma. These results show similar upregulated patterns of expression in two genes of the 6GS in endobronchial biopsies, previously identified in sputum. The upregulation ofDNASE1L3 andIL1B suggests that common mechanisms may be at play throughout the airway.

Source: Immunity, Inflammation and Disease - January 4, 2020 Category: Allergy & Immunology Authors: Stephany S ánchez‐Ovando, Katherine J. Baines, Daniel Barker, Peter A. Wark, Jodie L. Simpson Tags: ORIGINAL RESEARCH Source Type: research