Neurodevelopmental Abnormalities Associated With In Utero Zika Virus Infection

In the United States, more than 7400 pregnancies with laboratory evidence of confirmed or possible Zika virus infection were identified and included in the national surveillance network, the US Zika Pregnancy and Infant Registry, during the Zika virus outbreak in the Region of the Americas from 2015 to 2017. These pregnancies included those completed from December 1, 2015, through March 31, 2018, meaning the children from these pregnancies ranged in age from 18 months to nearly 4 years by the fall of 2019. Although between 5% and 10% of these children have received a diagnosis of serious defects of the brain or eye, including microcephaly, many of them have not undergone the recommended postnatal brain imaging and ophthalmological examinations to fully identify these health problems. Some infants with a standard head circumference measurement at birth may have underlying brain and/or eye defects. In a report from the US territories and freely associated states, 23 children without microcephaly had brain and/or eye defects that would have been missed without the recommended neuroimaging and/or ophthalmological examinations.
Source: JAMA Pediatrics - Category: Pediatrics Source Type: research

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by Anna Ramond, Ludmila Lobkowicz, Nuria Sanchez Clemente, Aisling Vaughan, Mar ília Dalva Turchi, Annelies Wilder-Smith, Elizabeth B. Brickley BackgroundRecent Zika virus (ZIKV) outbreaks in the Pacific and the Americas have highlighted clinically significant congenital neurological abnormalities resulting from ZIKV infection in pregnancy. However, little is known about ZIKV infections in children and adolescents, a group that is potentially vulnerable to ZIKV neurovirulence. MethodsWe conducted a systematic review on the clinical presentation and complications of children and adolescents aged 0 to 18 years with a ...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Zika virus (ZIKV) infection during pregnancy has severe consequences on the new-born. The World Health Organization declared the Zika outbreak to be a Public Health Emergency of International Concern (PHEIC) i...
Source: BMC Women's Health - Category: OBGYN Authors: Tags: Research article Source Type: research
[Mental health from the perspective of women affected by the Zika virus: an ethnographic study in Pará State, Brazil]. Cad Saude Publica. 2020;36(8):e00100019 Authors: Silva DAD, Silva ÉQ Abstract The current study reflects on the Zika virus outbreak that struck the Brazilian population, with both physical and emotional aspects for all those affected. There is a particular group that has to deal on a daily basis with all the difficulties imposed by this new reality: women. The basic assumption of this approach is the need to learn about, understand, and grasp these biopsychosocial issues...
Source: Cadernos de Saude Publica - Category: International Medicine & Public Health Authors: Tags: Cad Saude Publica Source Type: research
CONCLUSION: Some pregnant women are accepting of participation in vaccine research during infectious disease outbreaks. Incorporating their priorities into trial design may facilitate their participation and generation of evidence for this important population. PMID: 32893036 [PubMed - as supplied by publisher]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
The Zika Contraception Access Network (Z-CAN) was a short-term emergency response intervention that used contraception to prevent unintended pregnancy to reduce Zika-related adverse birth outcomes during the 2016-2017 Zika virus outbreak in Puerto Rico. Strategies and safeguards were developed to ensure women who chose long-acting reversible contraception (LARC) had access to no-cost removal, if desired, after Z-CAN ended.Study DesignWe assessed the number of women who chose LARC at their initial Z-CAN visit who filed complaints regarding challenges with LARC removal within 30-months after the Z-CAN program ended.
Source: Contraception - Category: OBGYN Authors: Source Type: research
ra RJ, Soriano A, Bentes GA, de Oliveira Bottino F, Salvador Castro Faria SB, Nudelman RF, Lopes CAA, Perea JAS, Sarges K, Andrade MCR, Motta MCVA, Freire MS, Souza TML, Schmidt-Chanasit J, Pinto MA Abstract The outbreaks of Zika virus (ZIKV) infection in Brazil, 2015-2016, were associated with severe congenital malformations. Our translational study aimed to test the efficacy of the antiviral agent sofosbuvir (SOF) against vertical transmission of ZIKV and the associated congenital syndrome (CZS), using a rhesus monkey model. Eight pregnant macaques were successfully infected during the organogenesis phase with a...
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
Abstract A sporadic but autochthonous dengue fever outbreak occurred in Tokyo in 2014, although the dengue virus is not in general circulation in Japan. Another lethal infectious disease, known as severe fever with thrombocytopenia syndrome (SFTS), was discovered to be endemic to Japan in January 2013. More than 400 patients with SFTS have been reported so far. The fatality rate of SFTS is approximately 30%. Also in 2014, a large outbreak of mosquito-borne Zika virus infections occurred in the South and Central parts of the American continent. Transplacental infection of a fetus with Zika virus occurs when pregnan...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research
In the year 2015 a temporal relation was observed between the increase in notifications of microcephaly and the outbreak of Zika virus (ZIKV) becoming a significant public health problem in Brazil (Nunes et al. 2016). This increase in cases of microcephaly favored the development of diagnostic guidelines with more accurate neonatal screening parameters to better evaluate infants exposed to maternal ZIKV infection. Changes in the fetal Central Nervous System (CNS), as well as in several other systems, have given rise to what is known as Congenital Zika Virus Syndrome (CZS) (Brito 2015; Schuler-Faccini et al.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Before the 2015 Zika virus (ZIKV) outbreak in Latin America, little attention had been paid to ZIKV, first discovered in 1947, mainly because of its mild symptoms and short duration, which were similar to other arboviral diseases. Now, however, an association between ZIKV infection and neurologic outcomes such as Guillain-Barr é Syndrome (GBS) in infected adults and central nervous system malformation of fetuses in infected pregnant women has been established.1 A recent systematic review found that microcephaly is the most commonly reported adverse outcome of ZIKV infection, followed by GBS.
Source: Value in Health - Category: International Medicine & Public Health Authors: Source Type: research
Conclusions: More detailed knowledge of ZIKV infection in children allows the pediatrician to diagnose earlier, implement the correct treatment, monitor warnings signs for the most severe forms, and especially establish effective preventive measures. ABBREVIATIONS: CDC, Centers for Disease Control; CZS, congenital Zika syndrome; DEET, N, N-diethyl-3-methylbenzamide; GBS, Guillain-Barré syndrome; PRNT, plaque reduction neutralisation test; RNA, ribonucleic acid; RT-PCR, reverse transcriptase polymerase chain reaction; STX, saxitoxin; ZIKV, Zika virus. PMID: 32576082 [PubMed - as supplied by publisher]
Source: Paediatrics and international child health - Category: Pediatrics Tags: Paediatr Int Child Health Source Type: research
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