Hyaluronan deposition in islets may precede and direct the location of islet immune-cell infiltrates

Conclusions/interpretationThis study indicates that HA deposition in islets occurs early in type 1 diabetes and prior to insulitis, and points to a potential role of HA in triggering islet immune-cell infiltration and the promotion of insulitis.

http://link.springer.com/10.1007/s00125-019-05066-7

Source: Diabetologia - January 5, 2020 Category: Endocrinology Source Type: research