Genetic disruption of slc4a10 alters the capacity for cellular metabolism and vectorial ion transport in the choroid plexus epithelium

ConclusionOur findings suggest that the lack of effective Na+-entry into the epithelial cells of the choroid plexus leads to a profound change in the cellular phenotype, shifting from a high-rate secretory function towards a more dormant state; similar to what is observed during ageing or Alzheimer ’s disease.

http://link.springer.com/10.1186/s12987-019-0162-5

Source: Fluids and Barriers of the CNS - January 6, 2020 Category: Neuroscience Source Type: research