Synthesis and Application of a Long-Circulating Radiolabeled Peptide for Targeting of Osteosarcoma

ConclusionsOverall, the introduction of the EB motif to TMTP1 significantly changed its pharmacokineticsin vivo, and this strategy fulfills the purpose of prolonging the blood circulation and enhancing the tumor uptake. [64Cu]DOTA-EB-TMTP1 is a promising agent for osteosarcoma targeting. Moreover, our study highlights that DOTA-EB-TMTP1 is a good candidate for labeling with different radionuclides for potential theranostic applications.

http://link.springer.com/10.1007/s11307-019-01468-6

Source: Molecular Imaging and Biology - January 5, 2020 Category: Molecular Biology Source Type: research