CD4+ T cell restoration and control of hepatitis C virus replication after childbirth

Chronic hepatitis C virus (HCV) infection is characterized by persistent high-level viremia and defective cellular immunity, including a lack of functional HCV-specific CD4+ T cells. We previously described an exceptional period of viral control that occurs in some chronically infected women after childbirth. Here, we investigated whether reduced HCV replication after pregnancy is associated with recovery of CD4+ T cell immunity. Class II tetramer analysis revealed significantly greater frequencies of circulating HCV-specific CD4+ T cells at 3 months postpartum in women with concurrent declines in viremia compared with those with stable viremia. These HCV-specific CD4+ T cells had an effector-memory phenotype. Inhibitory coreceptor expression on these cells corresponded to the degree of viral control. Circulating CD4+ T cells produced IL-2 and IFN-γ after HCV antigen stimulation, demonstrating Th1 functionality. These data provide direct evidence that the profound loss of HCV-specific CD4+ T cell help that results in chronic infection is reversible following pregnancy, and this recovery of CD4+ T cells is associated with at least transient control of persistent viral replication.
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research

Related Links:

Publication date: November 2020Source: European Journal of Obstetrics &Gynecology and Reproductive Biology, Volume 254Author(s): Silvano Piffer, Antonio Mazza, Laura Dell’Anna
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Publication date: Available online 16 September 2020Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Silvano Piffer, Antonio Mazza, Laura Dell’Anna
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
The study evaluates the trend over time and the results of serological screening for hepatitis C infection in pregnancy and obstetric and neonatal outcomes.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Full length article Source Type: research
The treatment of hepatitis C virus (HCV) infection during pregnancy is mainly focused on maternal cure, with the secondary aim of also preventing vertical transmission to the fetus. Direct-acting antivirals (DAAs) are commonly being prescribed to nonpregnant patients, but a lack of data on the pharmacokinetics, safety, and efficacy of DAAs hampers their use in pregnant patients.1 It has been hypothesized that ribavirin-free maternal treatment regimens with DAAs could be appropriate if it can be shown that treatment during pregnancy does not cause reproductive toxic adverse effect.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Research Letter Source Type: research
This study aimed to determine the viral hepatitis in pregnant women attending antenatal clinic, AMTHI. Informed consent questionnaire was administered before blood collection via venipuncture. a total of 904 pregnant women plasma samples were tested for HBV, HCV, and HEV using ELISA kit. Data was analyzed using packages within SPSS software and P ≤ 0.05 was considered significant. Out of 904 samples analyzed, the overall prevalence of hepatitis infections among pregnant women attending antenatal clinic in AMTHI was 66(7.3%). High prevalence of the hepatitis infections was found among young women within the age grou...
Source: Journal of Immunoassay and Immunochemistry - Category: Biochemistry Tags: J Immunoassay Immunochem Source Type: research
(Abstracted from JAMA 2020;323(10):976–992)
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: OBSTETRICS: MEDICAL COMPLICATIONS OF PREGNANCY Source Type: research
PMID: 32732756 [PubMed - in process]
Source: Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Obstet Gynecol Source Type: research
(University of Pittsburgh) Critics of the universal hepatitis C screening argue that it's wasteful to test pregnant women for a disease that can't be immediately treated, but results of a small phase I clinical trial suggest otherwise: pregnancy could be an excellent time to diagnose and cure hepatitis C infection.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Conclusion: The outbreak was due to HEV genotype 1A. The municipal water supply was contaminated and sanitary conditions and waste disposal were poor in the area. Boiling of drinking water, fixing the water supply pipes and frequent hand washing helped in controlling the outbreak.
Source: Indian Journal of Medical Microbiology - Category: Microbiology Authors: Source Type: research
Source: Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
More News: Biomedical Science | Hepatitis | Hepatitis C | Pregnancy | Women