Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells.

CONCLUSIONS: Our data show that human iPSC-derived beta cells respond to pro-inflammatory cytokines IL-1β + IFNγ and IFNα, by activating the same pathogenic processes as adult human primary beta cells. These cells thus represent a valuable tool for future research on the pathogenesis of type 1 diabetes. PMID: 31900242 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/31900242?dopt=Abstract

Source: Cell Research - January 2, 2020 Category: Cytology Authors: Demine S, Schiavo AA, Marín-Cañas S, Marchetti P, Cnop M, Eizirik DL Tags: Stem Cell Res Ther Source Type: research