Evidence for Relationship Between Early Dumping and Postprandial Hypoglycemia After Roux-en-Y Gastric Bypass

AbstractBackgroundEarly dumping and post-bariatric hypoglycemia (PBH) are often addressed as two separate postprandial complications after Roux-en-Y gastric bypass (RYGB). The aim of the study was to evaluate the occurrence of early dumping in RYGB-operated individuals with PBH with and without treatment intervention.MethodsEleven RYGB-operated women with documented PBH each underwent a baseline liquid mixed meal test (MMT) followed by five MMTs preceded by treatment with: acarbose 50  mg for 1 week, sitagliptin 100 mg for 1 week, verapamil 120 mg for 1 week, liraglutide 1.2 mg for 3 weeks, and pasireotide 300 μg as a single dose. Repetitive venous blood sampling and continuous electrocardiogram recordings were performed at fasting and during a 3-h postprandial period.ResultsDuring the baseline MMT, there was a significant increase in HR (from 65  ± 2 to 90 ± 4 bpm,p 
Source: Obesity Surgery - Category: Surgery Source Type: research

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ConclusionOur findings suggest that consumption of a cafeteria diet increases sympathetic drive to the heart but not to the blood vessels, independent of impairment in baroreflex and chemoreflex functions. Other mechanisms may be involved in the increased cardiac sympathetic drive, and compensatory vascular mechanisms may prevent the development of hypertension in this model of obesity.
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Conclusions: Neuromuscular clinics could benefit from implementing consistent and recommended growth assessment practices. The development of evidence-based tools, training and protocols tailored to Duchenne muscular dystrophy should be a priority.IMPLICATIONS FOR REHABILITATIONGrowth and weight monitoring approaches vary within and between neuromuscular clinics.Additional training on discussing and managing weight are warranted across disciplines.Advocacy is required to ensure access to dietetic expertise within neuromuscular clinics. PMID: 32058820 [PubMed - as supplied by publisher]
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research
Publication date: Available online 12 February 2020Source: Canadian Journal of CardiologyAuthor(s): Alexandre A. da Silva, Jussara M. do Carmo, Xuan Li, Zhen Wang, Alan J. Mouton, John E. HallAbstractHyperinsulinemia and insulin resistance were proposed more than 30 years ago to be important contributors to elevated blood pressure (BP) associated with obesity and the metabolic syndrome, also called syndrome X. Support for this concept initially came from clinical and population studies showing correlations among hyperinsulinemia, insulin resistance and elevated BP in individuals with metabolic syndrome. Short-term studies ...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Abstract Psychomotor stimulants are prescribed for many medical conditions including obesity, sleep disorders and attention deficit-hyperreactivity disorder. However, in spite of their acknowledged therapeutic utility these stimulants are frequently abused, and their use can have both short- and long-term negative consequences. Although stimulants such as amphetamines acutely elevate blood pressure, it is unclear whether they cause any long-term effects on cardiovascular function after use has been discontinued. Previous work in our laboratory has demonstrated that physiological and psychosocial stressors will pro...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - Category: Physiology Authors: Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research
Publication date: Available online 8 February 2020Source: Canadian Journal of CardiologyAuthor(s): Ernesto L. SchiffrinAbstractLarge conduit arteries and the microcirculation participate in the mechanisms of elevation of blood pressure (BP). Large vessels play roles predominantly in older subjects, with stiffening progressing after middle age leading to increases in systolic BP found in most humans with aging. Systolic BP elevation and increased pulsatility penetrate deeper into the distal vasculature, leading to microcirculatory injury and remodeling, and associated endothelial dysfunction. The result is target organ dama...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
ConclusionIn summary, we provide the first evidence that despite obesity, the ArcPomc-/- mouse model has high circulating adiponectin levels, which revealed that increased fat mass is not necessarily correlated with hypoadiponectinemia. Our investigation also uncovered a previously unknown physiological pathway connecting POMC neurons via the sympathetic nervous system to circulating adiponectin, thereby shedding light on the biological regulation of adiponectin.
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
We describe the case of a female patient proposed for laparoscopic bariatric surgery, conducted under an opioid-free anaesthesia protocol, the haemodynamic, ventilatory and analgesic control, and intra- and post-operative monitoring and complications.
Source: Indian Journal of Anaesthesia - Category: Anesthesiology Authors: Source Type: research
ConclusionsThis is the first report of a BBS patient with biallelic splice-siteBBS1 variants in the Japanese population. Disparity between funduscopic and ERG findings may be a feature ofBBS1-associated rod-cone dystrophy.
Source: Documenta Ophthalmologica - Category: Opthalmology Source Type: research
Abstract In males, obesity increases sympathetic nerve activity (SNA), but the mechanisms are unclear. Here, we investigate insulin, via an action in the arcuate nucleus (ArcN), and downstream neuropathways, including melanocortin receptor 3/4 (MC3/4R) in the hypothalamic paraventricular nucleus (PVN) and dorsal medial hypothalamus (DMH). We studied conscious and α-chloralose-anesthetized SD rats fed a high fat diet, in which obesity prone (OP) rats accrue excess fat, whereas obesity resistant (OR) rats maintain fat content like rats eating a standard control (CON) diet. Nonspecific blockade of the ArcN with...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - Category: Physiology Authors: Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research
Abstract Beige adipocytes have become a promising therapeutic target to combat obesity. Our senior author Xue previously discovered a transient but significant induction of beige adipocytes in mice during early postnatal development in mice, which peaked at postnatal day 20 (P20) and then disappeared thereafter. However, the physiological mechanism underlying the transient induction of the developmental beige cells remains mystery. Interestingly, there exists a postnatal surge of leptin in mice at postnatal day P10 prior to the appearance of the developmental beige adipocytes. Given the neurotropic effect of lepti...
Source: Am J Physiol Endocri... - Category: Endocrinology Authors: Tags: Am J Physiol Endocrinol Metab Source Type: research
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