Outcome of TiNi Stent Treatments in Symptomatic Central Airway Stenoses Caused by Aspergillus fumigatus Infections After Lung Transplantation
Xie BX, Zhu YM, Chen C, Zhao DP, Yang CL, Ding JA, Jiang GN
This study examined the relationship between post-transplant antifungal prophylaxis and freedom from CLAD.
Voriconazole is the drug of choice for prophylaxis and treatment of Aspergillus infection in LTx recipients. Voriconazole has a narrow therapeutic index; thus, therapeutic drug monitoring (TDM) is required to prevent treatment failure and reduce the risk of adverse drug events (ADE). We aim to determine the frequency and type of ADE associated with voriconazole and describe voriconazole dosing and TDM in LTx recipients.
Aspergillus fumigatus is responsible for Invasive aspergillosis (IA). The role of other closely related species such as Aspergillus lentulus and Aspergillus viridinutans which are members of the section Fumigati (A. fumigatus complex) in the setting of pre-emptive therapy in lung transplant recipients is not well defined, and may be associated with poor clinical response.
AbstractPurpose of ReviewTo describe the clinical features, diagnosis, and treatment of angioinvasive fungal infections.Recent FindingsCandida auris is a recently discovered species with multi- to pan-drug resistance to azoles, amphotericin B, and echinocandins. The SECURE trial showed that isavuconazole was non-inferior to voriconazole for treatment ofAspergillus. Additionally, the VITAL study showed that there was no difference in mortality between those treated with either isavuconazole or amphotericin B. Isavuconazole is now approved by the FDA for the treatment ofAspergillus andMucor.SummaryInvasive fungal infections ...
Rezafungin (RZF) is a novel echinocandin in development for prevention of invasive fungal disease caused by Candida, Aspergillus, and Pneumocystis species in patients undergoing blood and marrow transplantation. RZF has a favorable safety and tolerability profile, a low risk of drug-drug interactions and with its stability, pharmacokinetics that allow for once-weekly dosing with broad distribution to the lung and other fungal target organs.We previously demonstrated RZF efficacy in preventing Pneumocystis infection in an immunosuppressed mouse model.
Abstract Pulmonary lymphangioleiomyomatosis accounts for the majority of cadaveric lung transplantation cases. Post-transplantation management is continuingly necessary not only to prevent the progression of LAM but also to address complications. A woman with lymphangioleiomyomatosis underwent cadaveric lung transplantation. She developed post-operative native lung hyperinflation and hemoptysis with cavity shadow in the native lung on computed tomography. Isolated Aspergillus from her sputum and positive Aspergillus galactomannan antigen in the blood led to a diagnosis of aspergillosis. Despite the reduction of he...