Cystic fibrosis sufferer Natalie McCusker gains top exam results despite needing lung transplant

Natalie McCusker, from Greater Manchester, got four As and a B in her AS-levels while waiting for urgent treatment for cystic fibrosis.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Compositional changes in the microbiome are associated with the development of bronchiolitis obliterans (BO) after lung transplantation (LTx) in adults with cystic fibrosis (CF). The association between the lower airway bacterial community and BO after LTx in children with CF remains largely unexplored and is possibly influenced by frequent antibiotic therapy.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Journal of Palliative Medicine, Ahead of Print.
Source: Journal of Palliative Medicine - Category: Palliative Care Authors: Source Type: research
CONCLUSIONS: Patients who underwent Unplanned-Intraoperative ECMO showed poorer prognoses than patients who did not require ECMO. This finding may be explained by differences in initial condition severity, by long-term consequences of the intraoperative complications leading to ECMO pump implantation, or by flaws in our weaning protocol. PMID: 32380057 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research
AbstractThe pig is an omnivorous, monogastric species with many advantages to serve as an animal model for human diseases. There are very high similarities to humans in anatomy and functions of the immune system, e g., the presence of tonsils, which are absent in rodents. The porcine immune system resembles man for more than 80% of analyzed parameters in contrast to the mouse with only about 10%. The pig can easily be bred, and there are less emotional problems to use them as experimental animals than dogs or monkeys. Indwelling cannulas in a vein or lymphatic vessel enable repetitive stress-free sampling. Meanwhile, there...
Source: Cell and Tissue Research - Category: Cytology Source Type: research
Persistent air leak (PAL) is a common problem after secondary pneumothorax due to cystic fibrosis (CF). These leaks, caused by either bronchopleural or alveolopleural fistula, are associated with higher morbidity and mortality [1]. Air leaks are traditionally treated with chronic chest tube drainage, chemical pleurodesis, or autologous blood patching in non-surgical candidates [1]. However, these strategies can increase infectious risk or pleural scarring, which are associated with poorer lung transplant surgical outcomes.
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Source Type: research
This article reviews the specific imaging features of CF using conventional imaging modalities (chest radiographs and high-resolution computed tomography [HRCT]) as well as emerging imaging technologies (digital chest tomosynthesis and MR imaging). In addition, the authors review the CF-specific HRCT imaging findings that are essential in the evaluation of these patients in the pre-lung transplant and post-lung transplant settings. PMID: 32276698 [PubMed - as supplied by publisher]
Source: Radiologic Clinics of North America - Category: Radiology Authors: Tags: Radiol Clin North Am Source Type: research
Bilateral lung transplantation (LTx) is a complex but important therapeutic option for end-stage cystic fibrosis (CF) patients, with a significant risk of perioperative morbidity and mortality [1,2]. Patients should be referred for LTx when pulmonary function has declined to 30% of predicted Forced Expiratory Volume in 1  s (FEV1% predicted) or when worsening rapidly [1]. After LTx, pulmonary function, quality of life, and life expectancy can improve drastically [2,3].
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Source Type: research
Cystic fibrosis (CF) is today the second most common primary indication for bilateral lung transplantation in adults and the third most common indication for lung transplantation in adults overall according to the most recent Thoracic Transplant Registry Report of the International Society for Heart and Lung Transplantation (ISHLT) (1). In children and adolescents, CF is the commonest reason for transplantation reaching 2/3rd in children older than 11 years (2). In general, lung transplantation is considered a life-saving therapy option in well selected patients with respiratory failure due to advanced CF lung disease (3).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Editoria Source Type: research
Pseudomonas aeruginosa (PA) is an established risk factor for chronic lung allograft dysfunction (CLAD) after lung transplantation (LTx). PA eradication in cystic fibrosis patients prevents pulmonary function decline. Therefore, we investigated the effect of PA eradication after LTx on CLAD-free survival, graft survival and pulmonary function.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (746) Source Type: research
Lung transplantation (LTX) is an established therapy in selected patients with advanced cystic fibrosis (CF) lung disease. Resumption of employment after LTX is generally supported. In Switzerland, there is no data on long-term LTX employment in patients with CF.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (499) Source Type: research
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