Defining a comprehensive verotype using electronic health records for personalized medicine.

Defining a comprehensive verotype using electronic health records for personalized medicine.
J Am Med Inform Assoc. 2013 Sep 3;
Authors: Boland MR, Hripcsak G, Shen Y, Chung WK, Weng C
Abstract
The burgeoning adoption of electronic health records (EHR) introduces a golden opportunity for studying individual manifestations of myriad diseases, which is called 'EHR phenotyping'. In this paper, we break down this concept by: relating it to phenotype definitions from Johannsen; comparing it to cohort identification and disease subtyping; introducing a new concept called 'verotype' (Latin: vere = true, actually) to represent the 'true' population of similar patients for treatment purposes through the integration of genotype, phenotype, and disease subtype (eg, specific glucose value pattern in patients with diabetes) information; analyzing the value of the 'verotype' concept for personalized medicine; and outlining the potential for using network-based approaches to reverse engineer clinical disease subtypes.
PMID: 24001516 [PubMed - as supplied by publisher]

Source: Journal of the American Medical Informatics Association - September 3, 2013 Category: Information Technology Authors: Boland MR, Hripcsak G, Shen Y, Chung WK, Weng C Tags: J Am Med Inform Assoc Source Type: research