Cytotoxic activity of organotin carboxylates based on synthetic phenolic antioxidants and polycyclic bile acids

Publication date: Available online 3 January 2020Source: Journal of Organometallic ChemistryAuthor(s): T.A. Antonenko, D.B. Shpakovsky, D.А. Berseneva, Yu.A. Gracheva, L.G. Dubova, P.N. Shevtsov, O.M. Redkozubova, E.F. Shevtsova, V.A. Tafeenko, L.A. Aslanov, E.R. MilaevaAbstractTwo series of organotin(IV) carboxylates based on phenolic antioxidants RCOOH and R(CH2)2COOH (R = 3,5-di-tert-butyl-4-hydroxyphenyl) and natural bile (cholanic) acids of formulae (RCOO)2SnMe2 (1); (RCOO)2SnBu2 (2); (R(CH2)2COO)2SnMe2 (3); (R(CH2)2COO)2SnBu2 (4); (cholate)SnPh3 (5); (deoxycholate)SnPh3 (6); (lithocholate)SnPh3 (7); (cholate)SnMe3 (8); (deoxycholate)SnMe3 (9), and (lithocholate)SnMe3 (10) were synthesized and characterized by 1H, 13C NMR, IR and elemental analysis to study their antioxidant and cytotoxic potential. Compounds 1 and 2 were found by X-ray diffraction analysis to be monomers in the solid state; moreover, the carboxyl groups are coordinated bidentately through O atoms. The distorted octahedron geometry around the Sn center in the monocrystals of 1, 2 was revealed. The antioxidant activity of compounds as radical scavengers and reducing agents was evaluated in spectrophotometrical tests with stable radical DPPH, reduction of Cu2+ (CUPRAC method) and interaction with superoxide anion radical. Cytotoxicity in vitro of compounds has been estimated on human cancer (colon cancer HCT-116, lung carcinoma A549, breast cancer MCF-7, neuroblastoma SH-SY5Y) cell lines and normal fi...
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research