Pilot study utilizing MRI 3D TGSE PASL (arterial spin labeling) differentiating clearance rates of labeled protons in the CNS of patients with early Alzheimer disease from normal subjects.

DISCUSSION: Signal decay in normal age groups correlates with decay of T1blood, thus CSF paravascular flow egresses and is inseparable from venous outflow. The AD group correlates with decay rate T1CSF, indicating a proportion of labeled blood ultra-filtered within the brain (paravascular fluid) is retained. This provides indirect evidence of reduced paravascular clearance in AD. Further development may produce an efficient biomarker identifying neurodegenerative diseases and future treatment efficacy. PMID: 31897905 [PubMed - as supplied by publisher]
Source: Magma - Category: Radiology Authors: Tags: MAGMA Source Type: research