Epistane, an anabolic steroid used for recreational purposes, causes cholestasis with elevated levels of cholic acid conjugates, by upregulating bile acid synthesis (CYP8B1) and cross-talking with nuclear receptors in human hepatocytes - Petrov PD, Fern ández-Murga L, Conde I, Martínez-Sena T, Guzmán C, Castell JV, Jover R.

Anabolic-androgenic steroids are testosterone derivatives, used by body-builders to increase muscle mass. Epistane (EPI) is an orally administered 17 α-alkylated testosterone derivative with 2a-3a epithio ring. We identified four individuals who, after EPI...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news