Seasonal affective disorder and seasonal changes in weight and sleep duration are inversely associated with plasma adiponectin levels

Publication date: Available online 2 January 2020Source: Journal of Psychiatric ResearchAuthor(s): Faisal Akram, Claudia Gragnoli, Uttam K. Raheja, Soren Snitker, Christopher A. Lowry, Kelly A. Sterns-Yoder, Andrew J. Hoisington, Lisa A. Brenner, Erika Saunders, John W. Stiller, Kathleen A. Ryan, Kelly J. Rohan, Braxton D. Mitchell, Teodor T. PostolacheAbstractOverlapping pathways between mood and metabolic regulation have been increasingly reported. Although impaired regulation of adiponectin, a major metabolism-regulating hormone, has been implicated in major depressive disorder, its role in seasonal changes in mood and seasonal affective disorder-winter type (SAD), a disorder characterized by onset of mood impairment and metabolic dysregulation (e.g., carbohydrate craving and weight gain) in fall/winter and spontaneous alleviation in spring/summer, has not been studied previously. We studied a convenience sample of 636 Old Order Amish (53.8 (±15.5) years; 50.1% males), a population isolate with self-imposed restriction on network electric light at home, and low prevalence of total SAD (t-SAD = syndromal + subsyndromal). We calculated the global seasonality score (GSS) and estimated SAD and subsyndromal-SAD after obtaining Seasonal Pattern Assessment Questionnaires (SPAQs) and measured overnight fasting plasma adiponectin levels. We then tested associations between plasma adiponectin levels and GSS, t-SAD, winter-summer difference in self-reported sleep duration and se...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research