Hyperoside exhibits anticancer activity in non ‑small cell lung cancer cells with T790M mutations by upregulating FoxO1 via CCAT1.

In conclusion, hyperoside inhibited proliferation and induced apoptosis by upregulating FoxO1 via CCAT1 in T790M‑positive NSCLC both in vitro and in vivo, suggesting that hyperoside is a novel candidate for T790M‑positive NSCLC treatment. PMID: 31894285 [PubMed - as supplied by publisher]
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

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Sang Soo Kim Hypoxia-inducible factors (HIFs) induced by reduced O2 availability activate the transcription of target genes encoding proteins that play important roles in communication between cancer and stromal cells. Cancer cells were incubated under hypoxic conditions: H1299, A549 (NSCLC); Hep3B, HepG2 (HCC); HCT116, CT26 (Colon cancer); MCF-7, MDAMB231 (Breast cancer); MKN1, MKN5 (Gastric cancer); U87MG, SHSY5Y (Brain cancer); and SKOV3, SNU840 (Ovary cancer). All cells expressed HIF-1α and HIF-2α mRNA and proteins. However, cell proliferation of NSCLC, breast, gastric, and brain cancer cells u...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Abstract A series of new 1,6-dihydropyrimidin-2-thiol derivatives (scaffold A) as VEGFR-2 inhibitors has been designed and synthesized. Compounds 3a, 3b, 3e and 4b have been selected for in vitro anticancer screening by the National Cancer Institute. Compound 3e showed remarkable anticancer activity against most of the cell lines tested, where a complete cell death against leukemia, non-small cell lung cancer, colon, CNS, melanoma, and breast cancer cell lines was observed. In vitro five dose tests showed that compound 3e had high activity against most of the tested cell lines with GI50 ranging from 19 to 100 ...
Source: Bioorganic Chemistry - Category: Chemistry Authors: Tags: Bioorg Chem Source Type: research
This study was to investigate the effects of LS on proliferation, cell cycle and apoptosis in human non-small cell lung cancer A549 cells, and its possible molecular mechanisms. Cell proliferation activity was measured by Cell Counting Kit-8 (CCK-8) and 5-Ethynyl-2'- deoxyuridine (EdU) cell proliferation kit. Cell cycle was detected by propidium iodide (PI) flow cytometry. Apoptosis was detected by Annexin-V-FITC/PI method. Western blot was used to detect cycle and apoptosis-related proteins expression. These results showed that the proliferation activity of LS was significantly decreased in A549 cells, showing a dose- and...
Source: Acta Histochemica - Category: Biochemistry Authors: Tags: Acta Histochem Source Type: research
Lung cancer is the highest mortality cancer, leading to more deaths due to cancer than other histologies, including breast, prostate, colon, ovarian and pancreas [1,2]. Smoking is a major risk factor for lung cancer; however, a growing incidence of lung cancer in never-smokers has been observed. Lung cancer can be classified into two main categories: non-small cell lung cancer (NSCLC), comprising about 85% of all cases, and small cell lung cancer (SCLC), making up the remaining 15% [1]. Several novel targeted and immunotherapy agents have been incorporated into the treatment paradigm for NSCLC over the past two decades, bu...
Source: Clinical Oncology - Category: Radiology Authors: Tags: Editorial Source Type: research
CONCLUSION: MINCR sponges miR-708-5p to up-regulate CTNNB1 and activate Wnt/β-catenin pathway, thus promoting the development CC. Targeting MINCR might shed new light on the therapeutic strategies of CC. PMID: 32535381 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
AbstractA series of new C28-amino-lupanes bearing A-azepano- and A-seco-3-amino-fragments was synthesized from 3,28-dioximino-betulin and evaluated for cytotoxicity toward the NCI-60 cancer cell line panel and antimicrobial activity against key ESKAPE pathogens. A-azepano-28-amino-betulin exhibited remarkable activities with GI50 ranging from 1.16 to 2.27  μM against all panel with the highest activity toward leukemia, colon cancer, non-small cell lung cancer and breast cancer. The replacement of the hydroxyl group at C28 in the structure of azepanobetulin to the amino group did not show a strong effect on the cy...
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research
Background and objective Flubendazole is an anthelmintic and categorized in benzimidazole. Previous evidence indicates its suppression on proliferation of colon cancer and breast cancer cells. Our study aims to explore the effects of flubendazole on non-small cell lung cancer A549 and H460 cell lines and the underlying mechanism. Methods CCK-8 assay was used to detect the effect of flubendazole at different concentrations on viability of both cell lines A549 and H460. We used western blot to detect the expression levels of autophagy-related proteins p62 and LC3 after flubendazole treatment. Cells were transfected with tand...
Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research
236Objectives: Immune checkpoint inhibitors (ICI) is the backbone treatment of non-small cell lung cancers (NSCLC). However, only a minority of patients achieves a durable response, therefore development of novel biomarkers represents a paramount interest. Recent experiments in germ-free mice and human metagenomics sequencing studies, and the deleterious impact of antibiotics have revealed the key role of the gut microbiota in immuno-oncology. Indeed, higher bacterial diversity has been identified as novel biomarkers of response. Interestingly, 18F-FDG physiologic colonic uptake increases following treatment with antibioti...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Lung Cancer I Source Type: research
This study found a substantial difference in the number of agents available for use in the metastatic and adjuvant settings for non-small cell lung cancer, breast cancer, and colon cancer.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
Abstract Ruthenium compounds have shown to be promising alternatives to platinum(II) drugs. However, their clinical success depends on achieving mechanisms of action that overcome Pt-resistance mechanisms. Electron-deficient organoruthenium complexes are an understudied class of compounds which exhibit unusual reactivity in solution and may offer novel anticancer mechanisms of action. Here, we evaluate the in vitro and in vivo anticancer properties of the electron-deficient organoruthenium complex [(p-cymene)Ru(maleonitriledithiolate)]. This compound is found to be highly cytotoxic: 5 to 60 times more potent than ...
Source: ChemMedChem - Category: Chemistry Authors: Tags: ChemMedChem Source Type: research
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