Broadest ever therapeutic HPV vaccine to be tested in clinical trial

Treatment could clear up persistent infections and reduce risk of cervical cancerThe broadest vaccine yet that could clear up persistent HPV infections and reduce the risk of women developing cervical cancer is to be tested in a clinical trial.Human papillomavirus infections are common and are generally cleared by the body. However, about 10% of infections are not cleared, with persistent infections of certain types of HPV known to increase the risk of a number of cancers, including cervical cancer.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: HPV vaccine Medical research Cervical cancer UK news Science Health Women Life and style Society Vaccines and immunisation World news Source Type: news

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Authors: Mboumba Bouassa RS, Péré H, Jenabian MA, Veyer D, Meye JF, Touzé A, Bélec L Abstract Introduction: Human papillomavirus (HPV) play an important role in the pathogenesis of mucosal neoplasia. Considering that cervical cancer is the fourth common cancer in women worldwide and that the global incidence of both HPV-associated anal and oropharyngeal cancers is constantly increasing, especially in men, infection with HPV can be regarded as a worldwide concern. HPV-specific adaptive immune response which involve CD8+ cytotoxic T cells as well as humoral responses both coordinated by CD...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
Abstract Human papillomavirus (HPV) infection is the primary risk factor for cervical cancer. While the HPV vaccine significantly reduces the risk of HPV infection and subsequent cervical cancer diagnosis, underuse is linked to lack of knowledge of its effectiveness in preventing cervical cancer. The purpose of this study was to evaluate a cancer educational intervention (titled "MOVENUP") to improve knowledge of cervical cancer, HPV, and the HPV vaccine among predominantly African American communities in South Carolina. The MOVENUP cancer educational intervention was conducted among participants residin...
Source: Advances in Cancer Research - Category: Cancer & Oncology Authors: Tags: Adv Cancer Res Source Type: research
Although much has been published in recent years on differences in Papanicolaou (Pap) tests across sexual orientation, other aspects of cervical cancer prevention remain underexplored, such as human papillomavirus (HPV) vaccination, HPV co-tests, or abnormal Pap tests.
Source: Womens Health Issues - Category: Primary Care Authors: Tags: Original article Source Type: research
Conclusions Human papillomavirus tests are a critical component for cervical cancer screening, and understanding of these tests helps test results interpretation and patients' triage.
Source: Journal of Lower Genital Tract Disease - Category: OBGYN Tags: Management HPV Assoc Conditions Source Type: research
rrera-Saldaña María L. Garza-Rodríguez Persistent high-risk human papillomavirus (HR-HPV) infections play a major role in the development of invasive cervical cancer (CC), and screening for such infections is in many countries the primary method of detecting and preventing CC. HPV typing can be used for triage and risk stratification of women with atypical squamous cells of undetermined significance (ASC-US)/low-grade cervical lesions (LSIL), though the current clinical practice in Mexico is to diagnose CC or its preceding conditions mainly via histology and HR-HPV detection. Additional informati...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
AbstractWe assessed the association of state legislation with  adolescent human papillomavirus (HPV) vaccination rates in states that legislated information dissemination or administration of HPV vaccination. Using insurance claims, we calculated monthly HPV vaccination rates (November 2009–December 2017) among adolescents in states that passed HPV vaccinat ion legislation during that period: Missouri (July 2010), Kentucky (February 2012), Indiana (March 2013), Oregon (June 2013). We used segmented regression to estimate levels and trends of HPV vaccination rates, comparing pre-legislation to post-legislation se...
Source: Journal of Community Health - Category: International Medicine & Public Health Source Type: research
(Karolinska Institutet) The human papillomavirus (HPV) causes, amongst other diseases, cancer of the cervix and oropharynx. A Swedish-Finnish study published in The Journal of Infectious Diseases now shows that the most oncogenic HPV types can be eliminated, but only if both girls and boys are vaccinated. Both genders will be offered vaccination in Sweden as of 2020.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
CONCLUSION: The total fraction of malignant and pre-malignant lesions attributed to Human papillomavirus genotypes contained in the nonavalent vaccine is significant in both women and men, which turns this vaccine into a great asset in terms of Public Health. PMID: 32130098 [PubMed - as supplied by publisher]
Source: Acta Medica Portuguesa - Category: General Medicine Tags: Acta Med Port Source Type: research
The first HPV vaccines licensed targeted two HPV types responsible for most cervical cancers. A 9-valent vaccine (9vHPV), targeting 5 additional types, was introduced in 2016 and is currently the only HPV vacc...
Source: Infectious Agents and Cancer - Category: Cancer & Oncology Authors: Tags: Research Article Source Type: research
Human papillomavirus (HPV) is one of the most significant risk factors for cervical cancer. The HPV vaccine has a very significant impact on the incidence of cervical cancer. The present study aimed to investi...
Source: BMC Public Health - Category: Consumer Health News Authors: Tags: Research article Source Type: research
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