Canine vector-borne disease: mapping and the accuracy of forecasting using big data from the veterinary community.

Canine vector-borne disease: mapping and the accuracy of forecasting using big data from the veterinary community. Anim Health Res Rev. 2019 Jun;20(1):47-60 Authors: Self SCW, Liu Y, Nordone SK, Yabsley MJ, Walden HS, Lund RB, Bowman DD, Carpenter C, McMahan CS, Gettings JR Abstract Diagnosis, treatment, and prevention of vector-borne disease (VBD) in pets is one cornerstone of companion animal practices. Veterinarians are facing new challenges associated with the emergence, reemergence, and rising incidence of VBD, including heartworm disease, Lyme disease, anaplasmosis, and ehrlichiosis. Increases in the observed prevalence of these diseases have been attributed to a multitude of factors, including diagnostic tests with improved sensitivity, expanded annual testing practices, climatologic and ecological changes enhancing vector survival and expansion, emergence or recognition of novel pathogens, and increased movement of pets as travel companions. Veterinarians have the additional responsibility of providing information about zoonotic pathogen transmission from pets, especially to vulnerable human populations: the immunocompromised, children, and the elderly. Hindering efforts to protect pets and people is the dynamic and ever-changing nature of VBD prevalence and distribution. To address this deficit in understanding, the Companion Animal Parasite Council (CAPC) began efforts to annually forecast VBD prevalence in 2011. These forecasts provide veterin...
Source: Animal Health Research Reviews - Category: Veterinary Research Authors: Tags: Anim Health Res Rev Source Type: research

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In conclusion, the developed LAMP method has high specificity and good reproducibility for screening the E198A SNP of isotype-1 β-tubulin gene of H. contortus of field samples without using sophisticated equipment, providing useful technique for the rapid detection and thus prevention and control of benzimidazole resistant H. contortus infections.
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
In this study, we show upregulation of PfGCN5 upon nutrient stress condition. With the help of chromatin immunoprecipitation coupled high-throughput sequencing (ChIP-seq) and transcriptomic (RNA-sequencing) analyses, we show that PfGCN5 is associated with the genes that are important for the maintenance of parasite cellular homeostasis upon nutrient stress condition. Furthermore, we identified various metabolic enzymes as interacting partners of PfGCN5 by immunoprecipitation coupled with mass spectroscopy, possibly acting as a sensor of nutrient conditions in the environment. We also demonstrated that PfGCN5 interacts and ...
Source: Journal of Biosciences - Category: Biomedical Science Authors: Tags: J Biosci Source Type: research
Publication date: September 2020Source: Journal of Energy Chemistry, Volume 48Author(s): Bo Yuan, Di Hua, Xingxing Gu, Yu Shen, Li-Chun Xu, Xiuyan Li, Bing Zheng, Jiansheng Wu, Weina Zhang, Sheng Li, Fengwei HuoAbstractLithium-sulfur battery (Li–S) is considered as one of the new-generation rechargeable batteries with high performance because of its extremely high theoretical capacity, energy density, environmental harmony and low cost. However, low electrical and ionic conductivity of sulfur, safety concerns and parasitic reaction generated by the dissolved polysulfide species in electrolyte hinder the commercializa...
Source: Journal of Energy Chemistry - Category: Chemistry Source Type: research
Our weekly round-up of the best psychology coverage from elsewhere on the web Psychologists have long recognised that the field has a bias towards studying people from Western, educated, industrialized, rich, and democratic (WEIRD) societies. But how much is actually being done to correct this bias? Not enough, according to the experts interviewed by Michael Schulson in a story for Undark. This week the government announced plans to use lie-detector tests with convicted terrorists who have been released from prison. There’s just one problem, reports Hannah Devlin in The Guardian — they don’t work. While...
Source: BPS RESEARCH DIGEST - Category: Psychiatry & Psychology Authors: Tags: Weekly links Source Type: blogs
We report the case of a 20-year-old male from the department of Amazonas who presented with nine days of disease characterized by multiorgan failure (neurological, renal, hepatic, respiratory, and hematological involvement). He received antibiotic treatment, as well as, transfusion, dialysis, hemodynamic, and ventilatory support. Despite the severity of the clinical condition, he evolved favorably. YF was confirmed by Rt-PCR and positive serology was obtained for leptospira by ELISA and microagglutination. However, from a laboratory point of view, real co-infection by yellow fever and leptospira could not be demonstrated. ...
Source: Revista Peruana de Medicina de Experimental y Salud Publica - Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research
(University of Pennsylvania) The parasite Toxoplasma gondii need not infect a host immune cell to alter its behavior, according to a new study from the University of Pennsylvania School of Veterinary Medicine.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
AbstractSchistosomiasis is a neglected tropical parasitic disease which has been controlled by praziquantel for many decades; however, reemergence of praziquantel resistant strains has been a continuous threat. Therefore, the development of reliable antischistosomal vaccine is significantly demanded for optimal control. In the present study, comparison amongSchistosoma haematobium, Schsitosoma mansoni andPygidiopsis genata crude antigens was carried out by Sodium dodecyl sulphate polyacrylamide gel electrophoresis. Hyperimmunization of rabbits with tested parasites ’ crude antigens was done to obtain hyperimmune sera...
Source: Journal of Parasitic Diseases - Category: Parasitology Source Type: research
C-Mannosylation is a common modification of thrombospondin type 1 repeats present in metazoans and recently identified also in apicomplexan parasites. This glycosylation is mediated by enzymes of the DPY19 family that transfer α-mannoses to tryptophan residues in the sequence WX2WX2C, which is part of the structurally essential tryptophan ladder. Here, deletion of the dpy19 gene in the parasite Toxoplasma gondii abolished C-mannosyltransferase activity and reduced levels of the micronemal protein MIC2. The loss of C-mannosyltransferase activity was associated with weakened parasite adhesion to host cells and with red...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Glycobiology and Extracellular Matrices Source Type: research
The objective was to evaluate the factors affecting the occurrence of bovine demodecosis from the clinical aspects of injuries, blood profile, and the correlation with weight gain and the season of the year in Sindhi-breed animal management in a tropical environment. Thirty-three Sindhi-breed animals were used: 23 females and 10 males. Clinical examination diagnosed that 90% of the examined animals presented skin lesions characteristic of bovine demodecosis caused byDemodex bovis (P 
Source: Tropical Animal Health and Production - Category: Veterinary Research Source Type: research
Coendemicity between the human immunodeficiency virus (HIV) and Plasmodium parasites, the causative agents of acquired immunodeficiency syndrome (AIDS) and malaria, respectively, occurs in several regions around the world. Although the impact of the interaction between these two organisms is not well understood, it is thought that the outcome of either disease may be negatively influenced by coinfection. Therefore, it is important to understand how current first-line antiretroviral therapies (ART) might impact Plasmodium infection in these regions. Here, we describe the effect of 18 antiretroviral compounds and of first-li...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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