Management of sinonasal adenocarcinomas with anterior skull base extension
ConclusionsManagement of SNAC consists of histological diagnosis, radiological staging, radical surgery, and adjuvant radiation therapy. Neoadjuvant chemotherapy can be indicated in selected cases. The role of biotherapy and immune therapy still needs to be elucidated.
ConclusionsPositive FS analysis is a poor prognostic factor after PD for PDAC. It is significantly associated with a high rate of R1 resection at final histology, PDAC recurrence and poor survival.
Publication date: Available online 17 February 2020Source: Pathology - Research and PracticeAuthor(s): To Van Ta, Quang Ngoc Nguyen, Ha Hoang Chu, Van-Long Truong, Linh Dieu VuongAbstractKRAS, NRAS, and BRAF are potential tumor-driven genes that are involved in the RAS/RAF/MAPK signaling pathway. RAS/RAF mutations importantly contribute to colorectal tumorigenesis since they remain the activated status of downstream pathways without regulation of the upstream EGFR signal. However, it has not been unclear how epigenetic alterations involved in colorectal tumorigenesis mediated by KRAS, NRAS, or BRAF mutations. Therefore, in...
Modern Pathology, Published online: 17 February 2020; doi:10.1038/s41379-020-0497-0PD-L1 in small bowel adenocarcinoma is associated with etiology and tumor-infiltrating lymphocytes, in addition to microsatellite instability
British Journal of Cancer, Published online: 17 February 2020; doi:10.1038/s41416-020-0752-7TG01/GM-CSF and adjuvant gemcitabine in patients with resected RAS-mutant adenocarcinoma of the pancreas (CT TG01-01): a single-arm, phase 1/2 trial
Volume 48, Issue 1, December 2020, Page 639-647 .
We present a similar case in the jejunum diagnosed by double balloon enteroscopy (DBE). We present the case of a 64-year-old patient with multifactorial anemia and transfusional requirements and a flat lesion of 2 cm in the colon, which showed undifferentiated adenocarcinoma on histopathological analysis. PMID: 32054271 [PubMed - as supplied by publisher]
We describe two cases of nasal metastases from colorectal carcinoma, and discuss the presentation, diagnosis and management of the case. Such metastatic disease ultimately represents end-stage malignancy, and patients should be palliated. PMID: 32054259 [PubMed - as supplied by publisher]
We report a case of a 66 year old male with an unusual case of mucinous adenocarcinoma associated with fistula-in-ano. The presentation was typical for fistula-in-ano with anal pain and chronic discharge. Standard treatment with resection and seton were carried out. Subsequent review of the histology revealed underlying adenocarcinoma and upon review of MRI imaging showed possible extensive local invasion. Features of this case are discussed together with its implications, including treatment guidelines and typical MRI findings. Extensive pelvic resection and reconstruction was undertaken due to the locally advance disease...
CONCLUSIONS This research distinguished hub genes and relevant signal pathways, which contributes to our understanding of the molecular mechanisms, and could be used as diagnostic indicators and therapeutic biomarkers for gastric adenocarcinoma. PMID: 32058995 [PubMed - in process]
Authors: Ventura L, Scarlattei M, Gnetti L, Silini EM, Rossi M, Tiseo M, Sverzellati N, Bocchialini G, Musini L, Balestra V, Ampollini L, Rusca M, Carbognani P, Ruffini L Abstract OBJECTIVE: To evaluate the prognostic role of maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) measured by FDG-positron emission tomography (PET)/computed tomography (CT) in patients with primary lung adenocarcinoma undergoing surgical resection. METHODS: All consecutive patients undergoing curative surgery for primary lung adenocarcinoma at the Thoracic Surgery Unit of the Un...
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