The Endogenous Analgesia Signature in The Resting Brain of Healthy Adults and Migraineurs

Imaging studies link migraine pathophysiology to functional abnormalities in pain modulatory brain areas.57,75 When interictal migraineurs are exposed to evoked pain, the pain-modulatory areas become hyperactive, and the level of hyperactivity is associated with attack frequency and pain intensity.56,63,81,96 Migraineurs also exhibit an association between migraine clinical characteristics, and altered resting-state functional connectivity (rsFC) of mesencephalic, cingulate, insular and prefrontal brain areas involved in affective processing and descending inhibition of pain.
Source: The Journal of Pain - Category: Materials Science Authors: Tags: Original Reports Source Type: research