Inhibition of melanin production and tyrosinase activity by flavonoids isolated from Loranthus acutifolius.

Inhibition of melanin production and tyrosinase activity by flavonoids isolated from Loranthus acutifolius. Nat Prod Res. 2020 Jan 02;:1-4 Authors: Apaza Ticona L, Thiebaut Estrada C, Rumbero Sánchez Á Abstract Activity-guided fractionations of leaves and stems from Loranthus acutifolius led to the isolation of 2',4',6-trimethoxyflavone (1), 3',4',5-trihydroxy-6,7,8-trimethoxyflavone (2), 2'4'-dihydroxy-6'-methoxy-chalcone (3) and 4',5-dihydroxy-6,7,8-trimethoxyflavone (4). The potential for inhibition against melanin production and tyrosinase activity of these 4 compounds was tested in B16-F10 cells. 2',4',6-trimethoxyflavone, 3',4',5-trihydroxy-6,7,8-trimethoxyflavone, 2'4'-dihydroxy-6'-methoxy-chalcone and 4',5-dihydroxy-6,7,8-trimethoxyflavone showed an inhibitory activity of melanin production with IC50 of 3.6 ± 0.05 μM, 8.1 ± 0.05 μM, 1.6 ± 0.03 μM and 6.5 ± 0.05 μM, respectively. In addition, 2',4',6-trimethoxyflavone, 3',4',5-trihydroxy-6,7,8-trimethoxyflavone, 2'4'-dihydroxy-6'-methoxy-chalcone and 4',5-dihydroxy-6,7,8-trimethoxyflavone were able to inhibit tyrosinase activity with IC50 of 4.0 ± 0.03 μM, 11.3 ± 0.05 μM, 5.7 ± 0.02 μM and 8.6 ± 0.04 μM, respectively. This is the first time that these compounds are reported in the L. acutifolius species showing anti-melanogenic activities. PMID: 31894701 [PubMed - as supplied by publisher]
Source: Natural Product Research - Category: Biochemistry Authors: Tags: Nat Prod Res Source Type: research