[ASAP] Potent, Orally Bioavailable, and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b01768

Source: Journal of Medicinal Chemistry - January 2, 2020 Category: Chemistry Authors: James R. Corte* †, Donald J. P. Pinto*†, Tianan Fang†, Honey Osuna†, Wu Yang†, Yufeng Wang†, Amy Lai†, Charles G. Clark†, Jung-Hui Sun‡, Richard Rampulla‡, Arvind Mathur‡, Mahammed Kaspady§, Premsai Rai Neithnadka§, Yi-Xin Cindy Li Source Type: research