AJP Articles Named ‘Top Stories of 2019’ By NEJM Journal Watch Psychiatry

Two articles published last year in theAmerican Journal of Psychiatry have been named “top stories of 2019” by the editorial board ofNEJM Journal Watch Psychiatry.“As always, we looked for high clinical relevance, balanced with solid methodology, and every study we chose focused on improving clinicians' abilities to treat patients, whether by identifying the best options or highlighting the weaknesses of some once-touted approaches,” wrote Peter Roy-Byrne , M.D., editor-in-chief ofNEJM Journal Watch Psychiatry, in a post announcing the selection of top journal articles of the year. These are theAJP studies:•Olanzapine Versus Placebo in Adult Outpatients With Anorexia Nervosa: A Randomized Clinical Trial: Evelyn Attia, M.D., and colleagues found that while the antipsychotic olanzapine may help adults with anorexia nervosa gain some weight, the medication does not appear to reduce obsessionality —a characteristic psychological feature of anorexia nervosa. The findings were based on a trial of 152 adults aged 18 to 65 with anorexia, who were assigned to olanzapine or placebo for 16 weeks. The researchers, who saw the patients weekly, used the Yale-Brown Obsessive Compulsive Scale (YBOCS) i nterview and several other assessments to determine participants’ obsessionality, eating disorder severity, and other factors over the course of the trial. They found that olanzapine was associated with a significantly greater rate of weight gain than placebo (approximately 1 lb ...
Source: Psychiatr News - Category: Psychiatry Tags: AJP anorexia nervosa Evelyn Attia NEJM Journal Watch Psychiatry olanzapine Peter Roy-Byrne Sidney Zisook treatment-resistant depression VAST-D Source Type: research