Gypenosides Prevent H 2 O 2 -Induced Retinal Ganglion Cell Apoptosis by Concurrently Suppressing the Neuronal Oxidative Stress and Inflammatory Response

In conclusion, our data indicate that neuroprotection by Gp involves its antioxidation and anti-inflammation effects. Gp prevents apoptosis through a mitochondrial apoptotic pathway. This finding might provide novel insights into understanding the mechanism of the neuroprotective effects of gypenosides in the treatment of optic neuritis.

http://link.springer.com/10.1007/s12031-019-01468-9

Source: Journal of Molecular Neuroscience - January 1, 2020 Category: Neuroscience Source Type: research